Carbon monoxide (CO) is a physiological messenger with diverse functions in the kidney, including controlling afferent arteriole tone both directly and via tubuloglomerular feedback (TGF). We have reported that CO attenuates TGF, but the mechanisms underlying this effect remain unknown. We hypothesized that CO, acting via cGMP, cGMP-dependent protein kinase, and cGMP-stimulated phosphodiesteras...

The search for new molecules to fight Pseudomonas aeruginosa is of paramount importance. Carbon monoxide (CO) is known to act as an effective inhibitor of the respiratory chain in P. aeruginosa, but the practical use of this gas as an antibacterial molecule is hampered by its toxicity and difficulty to manipulate. Here, we show that a water-soluble CO releaser (CORM-3) possesses bactericidal pr...

Carbon monoxide (CO) has shown various physiological effects including anti-inflammatory activity in several diseases, whereas the therapeutic efficacy of CO on sepsis-induced acute kidney injury (AKI) has not been reported as of yet. The purpose of the present study was to explore the effects of exogenous CO on sepsis-induced AKI and nucleotide-binding domain-like receptor protein 3 (NLRP3) in...

Future Internet design demands revolutionary approaches unfettered by legacy constraints and concepts. This paper presents a clean-slate Concern-Oriented Reference Model (CORM) for architecting future computer networks based on novel network design principles. CORM realizes the network as a software-dependent complex system. It defines the network design space in terms of function, structure an...

AIM The objective of this study was to evaluate the potential of Gabing San Fernando (Xanthosoma spp.) corms as partial carbohydrate replacement for maize in finisher broiler production. MATERIALS AND METHODS The completely randomized design was utilized to investigate the effects of three finisher poultry diets prepared in varying amounts of cocoyam-corm meal set at 0% (control), 25%, and 50...

Proliferation of pancreatic stellate cells (PSCs) plays a cardinal role during fibrosis development. Therefore, the suppression of PSC growth represents a therapeutic option for the treatment of pancreatic fibrosis. It has been shown that up-regulation of the enzyme heme oxygenase-1 (HO-1) could exert antiproliferative effects on PSCs, but no information is available on the possible role of car...

Carbon monoxide-releasing molecules (CO-RMs) are compounds capable of delivering controlled amounts of CO within a cellular environment. Ruthenium-based carbonyls [tricarbonyldichloro ruthenium(II) dimer and tricarbonylchloro-(glycinato)ruthenium(II)] and boronacorbonates (sodium boranocarbonate) have been shown to promote vasodilatory, cardioprotective, and anti-inflammatory activities in a va...

This investigation was carried out to determine the effects of gamma radiation on germination characteristics gladiolus corms. experiment conducted through a factorial design in randomized complete block with three replications. Two factors included cultivars (Red Advance, White Prosperity, Amsterdam, and Rose Supreme) doses (0, 15, 25, 35, 45, 55, 65, 75 Gy). The results showed that corm weigh...

PURPOSE The main aim of the experiment is to examine the effect of CORM-2, a donor of carbon monoxide (CO), on oxidative stress in human plasma in vitro. In addition, it examines the effects of CORM-2 on the hemostatic parameters of plasma: the activated partial thromboplastin time (APTT), thrombin time (TT) and prothrombin time (PT). METHODS Human plasma was incubated for 5-60 min with diffe...

BACKGROUND Osteoarthritis (OA) is the most widespread degenerative joint disease. Inflamed synovial cells contribute to the release of inflammatory and catabolic mediators during OA leading to destruction of articular tissues. We have shown previously that CO-releasing molecules exert anti-inflammatory effects in animal models and OA chondrocytes. We have studied the ability of CORM-2 to modify...