Extensive anthropogenic terrestrial sedimentary deposits are well recognized in the geologic literature and are increasingly being referred to as legacy sediment (LS). Definitions of LS are reviewed and a broad but explicit definition is recommended based on episodically produced anthropogenic sediment. The phrase is being used in a variety of ways, but primarily in North America to describe po...

The purpose of this case report is to correlate clinical features of granular dystrophy using 820 nm optical coherence tomography (OCT) in order to determine the depth of intrastromal corneal deposits. We report a case of a 38-year-old man with granular dystrophy. After complete ophthalmologic examination the patient was submitted to OCT, using the Stratus OCT III, originally proposed for study...

PURPOSE To investigate the molecular basis of hereditary lattice corneal dystrophy (LCD) type IIIA associated with corneal amyloid deposits afflicting several members of a four-generation family. METHODS Histologic, immunohistochemical and biochemical studies were performed on corneal tissue samples obtained after perforating keratoplasty. DNA was extracted from peripheral blood leukocytes. A...

A 55-year-old man operated on for tractional retinal detachment secondary to proliferative diabetic retinopathy, receives topical treatment including ciprofloxacin eye-drops and ointment. Lost sight of for a month without stopping treatment, patient returns with a real crystallization of the cornea as central whitish and hard plates corresponding to deposits of fluoroquinolone. The treatment wa...

Corneal stromal dystrophies are a group of genetic disorders that may be caused by mutations in the transforming growth factor β-induced (TGFBI) gene which results in the aggregation and deposition of mutant proteins in various layers of the cornea. The type of amino acid substitution dictates the age of onset, anatomical location of the deposits, morphological features of deposits (amyloid, am...

PURPOSE To analyze the deposition of amyloid and its precursors in eyes of patients with familial amyloidosis, Finnish (FAF; Meretoja's syndrome), a hereditary systemic amyloidosis. METHODS Autopsy eyes from three patients with FAF and ten control eyes were studied by Congo red staining and with antibodies to the nonmutated part of gelsolin (GS-2C4), the mutated gelsolin Asn-187 fragment (AGe...

To present 2 cases with long-term relapse-free intervals only after limbo-keratoplasty but not after conventional penetrating keratoplasty in granular dystrophy.Retrospective review of the patient charts and photographs taken during long-term follow-up of 2 cases with granular dystrophy, in which 1 eye received penetrating keratoplasty and the fellow eye received penetrating limbo-keratoplasty....

Walsh and Howard (I947) were the first to describe the deposition of calcium salts in the corneae of patients with hypercalcaemia due to hyperparathyroidism. This finding was later supported by Cogan, Albright, and Bartter (1948), and Walsh and Murray (I953) described a further series of patients. Since then no further reports have appeared in the literature on this subject apart from a case de...

purpose: to characterize the histopathologic, electron microscopic and confocal scan features of ahram mineral water (amw)-induced keratopathy in cadaver corneas. methods: seven cadaver globes were examined, five of which were exposed to amw from the corneal side for different durations (30 seconds, 3, 15, 30, and 60 minutes) and the other two were considered as controls. after performing confo...