THE importance of the role played by changes in the thickness of the cornea in the induction of corneal vascularization has recently become increasingly recognized (Cogan, 1948; Ashton, Cook, and Langham, 1951; Langham, 1952, 1953; Ashton and Cook, 1953). However the relationship between the swelling and increase in opacity of the cornea to the rate and progress of vascularization of the cornea...

PURPOSE To perform a masked study to determine whether resolvin E1 (RvE1), a lipid-derived immunomodulator, could regulate the development of corneal haze and opacity-related myofibroblasts after opacity-generating high correction photorefractive keratectomy (PRK) in rabbits. METHODS Three groups of eight rabbits each were included in the study. Nine diopter (D) PRK for myopia was performed i...

PURPOSE The mouse has become an important wound healing model with which to study corneal fibrosis, a frequent complication of refractive surgery. The aim of the current study was to quantify changes in stromal ultrastructure and light scatter that characterize fibrosis in mouse corneal debridement wounds. METHODS Epithelial debridement wounds, with and without removal of basement membrane, w...

PURPOSE To compare the effects of early, mid, and late subconjunctival injection of bevacizumab on corneal neovascularization (NV) and conjunctivalization in a rabbit limbal insufficiency model. METHODS Limbal insufficiency was created surgically, and subconjunctival injections of 2.5 mg bevacizumab twice weekly for 1 month were started immediately (early group), 1 week (mid group), and 1 mon...

Purpose To demonstrate clearing of chronic corneal opacities and improvement of visual acuity with the use of BostonSight prosthetic replacement of the ocular surface ecosystem (PROSE) treatment in ocular surface disease. Observations We undertook retrospective analysis of the medical records of a series of patients who underwent PROSE treatment from August 2006 to December 2014. Patients wer...

PURPOSE To evaluate the relative effectiveness and safety of LASIK using the Femto LDV (Ziemer Ophthalmic Systems AG) and IntraLase FS 60 (Abbott Medical Optics Inc) femtosecond lasers in patients with corneal opacity. METHODS Patients with corneal opacity were retrospectively selected between March and July 2009. For this study, 205 eyes with 90-μm corneal flaps created using the Femto LDV (...

An in vitro test for the development of corneal opacity in response ocular irritants was first proposed by Muir (1984). This test required the clamping of a bovine cornea between two chambers filled with physiologic saline and measuring the transmittance of white light through the cornea using the voltage output of a photocell. This was followed by exposure of the epithelial surface of the corn...

The purpose of the study is to report the visual, refractive, and wound healing pattern outcomes of femtosecond assisted deep anterior lamellar keratoplasty (DALK) compared to the conventional manual technique. DALK was performed on 50 eyes of 47 advanced keratoconus patients. The patients were divided into two groups, 25 eyes each, depending on whether femtosecond assisted or manual DALK techn...