Large proximal and smaller distal coronary arteries respond differently to pharmacologic agents, but the role of autoregulation is not known. We examined this role in dogs by cannulating the main left coronary artery and a distal left anterior descending artery branch. With coronary flow held constant, the distal coronary artery pressure and the gradient from proximal to distal artery were prop...

Coronary heart disease has been one of the main threats to human health. Coronary angiography is taken as the gold standard for the assessment of coronary artery disease. However, sometimes the images are difficult to visually interpret because of the crossing and overlapping of vessels in the angiogram. Also due to the low contrast of the image between the backdrop and the small blood vessels,...

Large proximal and smaller distal coronary arteries respond differently to pharmacologic agents, but the role of autoregulation is not known. We examined this role in dogs by cannulating the main left coronary artery and a distal left anterior descending artery branch. With coronary flow held constant, the distal coronary artery pressure and the gradient from proximal to distal artery were prop...

objectives to evaluate predictive value of vessel specific coronary artery calcium (cac) score in predicting obstructive coronary artery disease. patients and methods in this diagnostic test study we evaluated patients with coronary computed tomography angiography (ccta) and cac score which had been referred to two referral radiology center in tehran, iran and finally we selected 2525 patients ...

Cardiovascular diseases including coronary artery disease are the leading cause of death worldwide. Unraveling the developmental origin of coronary vessels could offer important therapeutic implications for treatment of cardiovascular diseases. The recent identification of the endocardial source of coronary vessels reveals a heterogeneous origin of coronary arteries in the adult heart. In this ...

The clinical role of collateral vessels was evaluated during transient coronary occlusion by percutaneous transluminal coronary angioplasty in 22 patients with (8) and without (14) collateral vessels. Coronary occlusion pressure, the ratio of mean coronary occlusion pressure to mean aortic pressure and myocardial perfusion pressure at 40 s of balloon inflation were significantly higher in patie...

Coronary artery disease accounts for 54% of all cardiovascular disease in the United States. Understanding how coronary vessels develop is likely to uncover novel drug targets and therapeutic strategies that will be useful in directing the repair or remodeling of coronary vessels in adults. Recent insights have identified the importance of cells derived from the proepicardium and epicardium in ...

background and aims: bilirubin has been considered an antioxidant that protects against atherosclerosis. the aim of this study was to evaluate the relationship of serum bilirubin level with the severity and complexity of coronary artery disease (cad) and long-term outcome in the patients undergoing primary percutaneous coronary intervention (pci). materials and methods: this prospective cohort ...

Despite the profound impact of coronary artery disease on human health, the origins of the coronary blood vessels are poorly understood. Wu et al. use imaging and genetic techniques to show that the endocardium contributes to the coronary vessels and that the coronary arteries and veins have multilineage origins.