I present a dynamic bioenergetic model that couples individual energetics and population dynamics to predict current lizard ranges and those following climate warming. The model predictions are uniquely based on first principles of morphology, life history, and thermal physiology. I apply the model to five populations of a widespread North American lizard, Sceloporus undulatus, to examine how g...

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BACKGROUND Researchers evaluating angiomodulating compounds as a part of scientific projects or pre-clinical studies are often confronted with limitations of applied animal models. The rough and insufficient early-stage compound assessment without reliable quantification of the vascular response counts, at least partially, to the low transition rate to clinics. OBJECTIVE To establish an advan...

Session 1 of the 2010 STP/IFSTP Joint Symposium on Toxicologic Neuropathology, titled "Fundamentals of Neurobiology," was organized to provide a foundation for subsequent sessions by presenting essential elements of neuroanatomy and nervous system function. A brief introduction to the session titled "Introduction to Correlative Neurobiology" was provided by Dr. Greg Hall (Eli Lilly and Company,...

Correlative light electron microscopy (CLEM) combines the advantages of light and electron microscopy, thus making it possible to follow dynamic events in living cells at nanometre resolution. Various CLEM approaches and devices have been developed, each of which has its own advantages and technical challenges. We here describe our customized patterned glass substrates, which improve the feasib...

In this paper, we propose a novel representation of sequences based on the structural information of the sequences. A sequence is represented by a set of rules, which are derived from its subsequences. There are two types of subsequences of interest. One is called frequent pattern, which is a subsequence appearing often enough in the sequence. The other is called correlative pattern, which is a...

Modems for digital communication often adopt the socalled correlative level coding or the partial-response signaling, which attains a desired spectral shaping by introducing controlled intersymbol interference terms. In this paper, a correlative level encoder is treated as a linear finite-state machine and an application of the maximumlikelihood decoding (MLD) algorithm, which was originally pr...

Two major approaches address the need to predict species distributions in response to environmental changes. Correlative models estimate parameters phenomenologically by relating current distributions to environmental conditions. By contrast, mechanistic models incorporate explicit relationships between environmental conditions and organismal performance, estimated independently of current dist...

Fluorescence resonance energy transfer (FRET) analysis and the recently developed proximity ligation assay (PLA) are widely used to study protein-protein interactions in situ. We have developed correlative FRET-PLA to monitor interactions between membrane proteins that frequently cause problems in confirmatory co-immunoprecipitation assays. Correlative FRET-PLA is particularly aimed at deliveri...