It was reported (1) that the hexokinase reaction, glucose + adenosine triphosphate + glucose-&phosphate + adenosine diphosphate, in extracts of muscle from diabetic rats could be inhibited by adrenal cortical extract, while the hexokinase activity in extracts of normal muscle was inhibited by a combination of anterior pituitary and adrenal cortical extracts. The inhibition was in both cases rel...

The binding of concanavalin A (Con A) to Strongylocentrotus purpuratus eggs has been investigated using 125I-concanavalin A (125I-Con A). The lectin binds specifically to the egg surface and does not produce agglutination of the eggs. High 125I-Con A concentrations are necessary to saturate all of the surface binding sites. Scatchard plots of the binding data are biphasic and may be interpreted...

Electrophoretic patterns of phosphorylated components from kidney cortical and medullary plasma membranes show clear differences. Radioautography of a dried-slab sodium dodecyl sulfate (SDS)-polyacrylamide gel reveals that at least 18 phosphorylated components can be resolved from cortical membranes after incubation with 5 PM [Y-~‘P]ATP. Fifteen components are resolved from medullary membranes....

W H E N a monospermic egg is fertilized, the attachment of the fertilizing spermatozoon to the egg surface provokes a protective reaction that prevents all but one spermatozoon from entering the egg; this is the block to polyspermy. The nature of the defence mechanism against polyspermy has been the subject of many investigations, performed mainly on the eggs of sea urchins. It was established ...

In Parkinson's disease (PD) degeneration of mesocortical dopaminergic projections may determine cognitive and behavioral symptoms. Choice reaction time task is related to attention, working memory, and goal-directed behavior. Such paradigm involves frontal cortical circuits receiving mesocortical dopamine which are affected early in PD. The aim of this study is to characterize the role of dopam...

Prolonged wakefulness is associated with obvious changes in the way we feel and perform. Are these changes paralleled by measurable changes in the state of cortical circuits? We show that human cortical excitability, reflected in the immediate (0-20 ms) electroencephalographic reaction to transcranial magnetic stimulation (TMS), progressively increases with time awake, from morning to evening a...

Cortical dysplasia accounts for at least 14% of epilepsy cases, and is mostly seen in children. However, the understanding of molecular mechanisms and pathogenesis underlying cortical dysplasia is limited. The aim of this cross-sectional study is to identify potential key molecules in the mechanisms of cortical dysplasia by screening the proteins expressed in brain tissues of childhood cortical...