The nuclear receptor corepressor N-CoR plays a crucial role in the repressive activity of diverse transcription factors, yet little is known about what regulates its cellular level. We have found that estrogen markedly down-regulates N-CoR protein levels in estrogen receptor (ER)-positive breast cancer cells without affecting N-CoR mRNA levels, whereas levels of the related corepressor SMRT are...

BACKGROUND Considered the leading cause of developmental disabilities worldwide, fetal alcohol spectrum disorders (FASD) are a global health problem. To take advantage of neural plasticity, early identification of affected infants is critical. The cardiac orienting response (COR) has been shown to be sensitive to the effects of prenatal alcohol exposure and is an inexpensive, easy to administer...

A ruthenium(II) complex coordinated by cordycepin, [Cor‑Ru(II)], was synthesized for investigation as a potential novel candidate for cancer therapy. The antitumor activity of Cor‑Ru(II) was investigated by MTT and flow cytometry (FCM) assays. The results showed that Cor‑Ru(II) significantly inhibited the proliferation of Bel‑7402 human hepatoma cells and delayed cell cycle progression. Subsequ...

in the presented work, sulfur concrete and rubber were used for producing functionally graded materials (fgm). the physical and mechanical properties of sulfur concrete and rubber were changed continuously across the thickness. on one side, there was just rubber and, on the other, there was pure sulfur; the properties of each substance were moved to reach another. this kind of material was cons...

and troughs of the individual rhythms varied widely over the 24-h period with no evidence of synchronization among individuals or a clear relationship with the light– dark cycle [mean (SD) copeptin concentration, 4.3 (1.5) pmol/L; 11.4 (3.6) pulses/24-h period ; mean pulse height, 5.1 (1.8) pmol/L] (Fig. 1). Interestingly, the expected large increase in cortisol during the second half of the ni...

Humic substances (HS) are often used as feesd additives in livestock feeding. The long-term effects of different concentrations HS aquafeed on growth and production performance, antioxidant status, stress resistance, gut microbiome, overall health condition, final product yield, sensory properties fresh cooked meat, composition fatty acids market size African catfish (Clarias gariepinus) origin...

SUMMARY Successful pathogen infection likely involves the suppression of general antimicrobial host defences. One Pseudomonas syringae virulence factor proposed to act in this manner is coronatine (COR), a phytotoxin believed to function as an analogue of one or more jasmonates, a family of plant growth regulators. COR biosynthetic (COR(-)) mutants of P. syringae pv. tomato strain DC3000 exhibi...

Coronatine [COR] is a novel type of plant growth regulator with similarities in structure and property to jasmonate. The objective of this study was to examine the relationship between increased root vitality induced by 10 nM COR and reactive oxygen species scavenging under potassium (K)-replete (2.5 mM) and K-deficient (0.05 mM) conditions in hydroponic cultured cotton seedlings. K-replete and...

BACKGROUND Laryngeal squamous cell carcinoma (LSCC) is a head and neck cancer type. In this study, we introduced a novel inflammation- and nutrition-based prognostic system, referred to as COR-BMI (Combination of red blood cell distribution width and body mass index), for LSCC patients. METHODS A total of 807 LSCC patients (784 male and 23 female, 22-87 y of age) who underwent surgery were en...

BACKGROUND Hazelnut (Corylus avellana) allergy exhibits age and geographically distinct sensitization patterns that have not yet been fully resolved. OBJECTIVE To study sensitization to Cor a 11 in different age groups of hazelnut-allergic patients and infants with atopic dermatitis (AD) sensitized to hazelnut in a birch-endemic region. METHODS Sera from 80 hazelnut-allergic patients, 33 in...