We recently reported the identification of a novel human adenosine A3 receptor-selective agonist, (2S,3S,4R,5R)-3-amino-5-[6-[5-chloro-2-(3-methylisoxazol-5-ylmethoxy)benzylamino]purin-9-yl]-4-hydroxytetrahydrofuran-2-carboxylic acid methylamide (CP-608,039), with 1,260-fold selectivity for the human A3 versus human A1 receptor (DeNinno et al., J Med Chem 46: 353-355, 2003). However, because th...

Abstract Diet composition and intake are the main determinants of nitrogen (N) use efficiency (NUE) in beef cattle. Accounting for interactions comparative effects different feedstuff types on NUE N losses urine faeces can inform development financially environmentally sustainable feeding protocols This study aimed to assess impact various individual feedstuffs types/groups partitioning cattle,...

Methylene blue (MB) was used as a model molecule to characterize the aqueous reactivity of metallic iron in Fe(0)/H(2)O systems. Likely discoloration mechanisms under used experimental conditions are: (i) adsorption onto Fe(0) and Fe(0) corrosion products (CP), (ii) co-precipitation with in situ generated iron CP, (iii) reduction to colorless leukomethylene blue (LMB). MB mineralization (oxidat...

The aim of the experiment was to assess an effect rainfall, temperature and fertilization on grassland dry matter (DM) production quality. Five treatments control (C0N), PK, N50PK, N100PK N150PK were established in western part “Zvolenská kotlina” basin (Slovakia) alluvial meadow. paper consists experimental data collected during 11 years (2008 – 2018). highest DM found treatment with rate 150 ...

von Willebrand factor-cleaving protease (vWF-cp) is responsible for the continuous degradation of plasma vWF multimers released from endothelial cells. It is deficient in patients with thrombotic thrombocytopenic purpura, who show unusually large vWF multimers in plasma. Purified vWF-cp may be useful for replacement in these patients, who are now treated by plasma therapy. In this study, vWF-cp...

BACKGROUND Chlamydia pneumoniae (Cp) infection has been associated with atherosclerosis, and a beneficial effect of antibiotic therapy on future cardiovascular events was described. METHODS AND RESULTS We evaluated the effect of roxithromycin therapy (150 mg twice daily for 30 days) on the progression of the intima-to-media thickness (IMT) of the common carotid artery using duplex ultrasonogr...

OBJECTIVES Currently established first line therapy of acute (presumed bacterial) rhinosinusitis (ARS) consists of 10 to 14 days of oral amoxicillin or cephalosporins. This study compared the clinical efficacy and tolerance of cefcapene pivoxil (CP) and amoxicillin-clavulanate (AMC) in patients with ARS. METHODS A randomized, open labeled, double-blinded trial of ARS patients over 15 years of...

As an important attribute of facial expression, emotional valence has been well explored, but its processing mechanisms remain ambiguous. Investigating the categorical perception (CP) of emotional valence might help uncover the objective basis of the subjective dichotomy of emotional valence and identify the stage at which this processing of valence information might occur. A judgment task was ...