BACKGROUND Our study aimed to evaluate final height in a cohort of Dutch childhood cancer survivors (CCS) and assess possible determinants of final height, including height at diagnosis. PATIENTS AND METHODS We calculated standard deviation scores (SDS) for height at initial cancer diagnosis and height in adulthood in a cohort of 573 CCS. Multivariable regression analyses were carried out to ...

PURPOSE Assess the intellectual and academic outcomes as well as risk factors associated with treatment for average-risk medulloblastoma in childhood using 23.4 Gy of craniospinal radiotherapy plus adjuvant chemotherapy. METHODS From an overall sample of 379 enrolled in the parent study (COG A9961), 110 patients received a total of 192 assessments over more than 5 years with standardized IQ a...

OBJECTIVE To determine the rate of second tumors in pediatric patients treated with radiotherapy to the central nervous system (CNS) with long-term follow-up. METHODS We retrospectively reviewed the charts of 370 consecutive pediatric patients with solid tumors and leukemia treated at the University of Florida from 1963 to 2006 with curative CNS radiotherapy. The median age was 8.1 years (ran...

www.thelancet.com/oncology Published online August 11, 2016 http://dx.doi.org/10.1016/S1470-2045(16)30390-4 1 The proportion of children with medulloblastoma receiving deferred postoperative radiotherapy more than tripled in the USA from 2004 to 2012, according to new research. Benjamin Kann (Yale University School of Medicine, New Haven, CT, USA) and colleagues examined the records of 816 pati...

Abstract Background The leptomeningeal dissemination (LMD) in the course of gliomas is rare. According to literature it can affect 4.7% all patients with gliomas. LMD be diagnosed at initial presentation or time recurrence. standard therapy has not yet been determined. We aimed present clinical features and prognosis retrospective analysis National Institute Oncology Gliwice, Poland experience....

Abstract Adult-onset medulloblastoma is a rare tumor for which limited data exists. Current treatment based on from childhood medulloblastoma. We present retrospective cohort of 130 consecutive patients age ≥ 18 years and treated at the University Washington (N = 61), Florida 50), Stanford 19), 2000-2021. Median duration follow-up was 57.3 months. Patients were 57.7% male (75/130), with median ...

The benefits of radio-chemotherapy in HIV-negative primary central nervous system (CNS) lymphomas were analyzed in 40 patients, who received radiotherapy to the brain or craniospinal axis with the total dose of 4460-5940 cGy to the primary tumor. Radiotherapy was followed by systemic chemotherapy, mainly with the cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) regimen, in 16 ...

Craniospinal penetrating foreign body (FB) injuries are interesting, but rarely observed, cases. They are important in terms of the complications that they may cause. The etiologies of craniospinal penetrating injuries and intracranial FB are also different. Though a sewing needle is more rarely seen in an intracranial FB, it may occur as atttempted infanticide or as a result of an accident esp...