objective: cyclosporine (cs), a cyclic undecapeptide with potent immunosuppressive activity, causes several adverse effects including reproductive toxicity. this study aims to examine the ability of crataegus monogyna aqueous fruit extract as an antioxidant to protect against cs-induced reproductive toxicity. materials and methods: in this experimental study, 32 adult male wistar rats were divi...

cyclophosphamide (cp) is extensively used as an antineoplastic agent for the treatment of various cancers, as well as an immunosuppressive agent. however, despite its wide spectrum of clinical uses, cp is known to cause several adverse effects including reproductive toxicity. crataegus monogyna is one of the oldest pharmaceutical plants that have been shown to be cytoprotective by scavenging fr...

OBJECTIVE Digitalis preparations are commonly used by children and adults with heart diseases worldwide, although excessive doses may cause cardiac effects. The aim of the study is to evaluate the antiarrhythmic effect of Crataegus oxyacantha extract on digoxin-induced arrhythmias in anesthetized Wistar rats. METHODS Control and experimental groups were evaluated for arrhythmias induced by di...

Polyphenols constitute a distinct group of natural compounds of medicinal importance exhibiting wide range of physiological activities as antioxidant, immunestimulant, antitumor and antiparasitic. Yellow fever and dengue fever are mosquito-borne infectious diseases transmitted by Aedes aegyptii, the presence of yellow fever in Sudan and dengue fever in Saudi Arabia are threats to Egypt with the...