Serum creatine phosphokinase (CPK) activity in 70 normal newborns was found to be significantly higher than the normal values found in adults or older children, and in some cases reached a level up to 10 times normal. It declined to near normal activity during the first 4 days and to normal level of activity by age 6-10 weeks. No clear correlation between birth trauma and increase in serum CPK ...

In a group of patients suffering from manic depressive illness treated with lithium carbonate occasional large increases in creatine phosphokinase (C.P.K.) activity were seen. These were found to occur at times when the patients were stable in mood and clinically well. The serum lithium levels were adequate in all cases at the time of raised C.P.K. activity. Raised C.P.K. activity can be an ind...

Study of the serum creatine kinase levels in young patients with facioscapulohumeral muscular dystrophy suggests that enzyme assay may be valuable as a screening procedure for assessing the status of relatives of an affected individual who have no previous clinical history, and that consequently it may be of use in genetic counselling.

Determination of serum creatine phos~hokinase (CPK; EC 2.7.3.2.) is important ill laboratory diagnosis of myocardial infarction (M') and skeletal muscle disorders (7). Two recent reports suggest that administration of corticosteroids decreases serum CPK activity (1.5). If patients with MI and myopathies are given. corticosteroids as some of them are the corticostEroids may ~revent the expected ...

Since the initial report on the clinical value of serum glutamic oxalacetic transaminase (SGOT) determinations in the diagnosis of myocardial infarction (LaDue, Wroblewski, and Karmen, 1954), a considerable amount of work has been done on the blood levels of other enzymes liberated from necrosed heart cells. Because of lack of specificity and difficulty of estimation, very few other enzyme esti...