Toll-like receptors (TLRs) are major receptors that enable inflammatory cells to recognize invading microbial pathogens. MicroRNAs are small non-coding RNAs that play important regulatory roles in a variety of biological processes. In this study, we found that a microRNA, miR-147, was induced upon stimulation of multiple TLRs and functioned as a negative regulator of TLR-associated signaling ev...

A series of benzylamino inhibitors of acetylcholinesterase (AChE) have been designed based on a working hypothesis of the enzyme s active site. These compounds were tested for their inhibitory activities on AChE and potent inhibitors were further evaluated in terms of central selectivity. These studies led to a discovery of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4, 5-tetrahydro-1H-1-benzazep...

We consider a risk-averse entrepreneur who invests in a project with idiosyncratic risk. In contrast to the literature, we assume the entrepreneur is unable to get a loan from a bank directly because of the low creditability of the entrepreneur and so an innovative financial contract, named equity-forguarantee swap, is signed among a bank, an insurer, and the entrepreneur. It is shown that the ...

The breadth and depth of ESL learners’ vocabulary knowledge and their comprehensive linguistic competence are not well studied in current literatures on vocabulary studies. This paper explores the creditability of depth and breadth of ESL learners’ vocabulary knowledge as an indicator of their overall linguistic competence and the correlation between depth and breadth of ESL learners’ vocabular...

The theory and technology of cloud computing have been widely adopted by many small and medium enterprises and individuals for their business systems or personal affairs. To facilitate the evaluation processes of cloud service creditability, the present paper proposed a new multi-attribute evaluation theory. In addition, a utility and collaborative filtering-based evaluation method was presente...

Rabeprazole sodium (RAB) is an anti-secretory agent which inhibits the enzyme H+/K+ ATPase, present in the stomach parietal cells. The aim of this work is to develop and validate a simple and fast ultraviolet spectrophotometric method (UV) for quantification of RAB in pharmaceutical formulation and compare it with a capillary electrophoresis (CE) one, previously validated. The UV technique was ...

Patients with hepatocellular carcinoma (HCC) experience poor prognosis and low survival rates. In this study, we explored the molecular mechanism of microRNA-147 (miR-147) in regulating human HCC. We firstly used quantitative RT-PCR (qRT-PCR) to compare the expression levels of miR-147 between 7 HCC and two normal liver cell lines, as well as 10 paired primary HCC tissues and their adjacent non...

To facilitate the research of mobile robot based odor source localization (OSL) and evaluate different strategies for the OSL, numerical simulation of odor plume in indoor ventilated environments is addressed. On the basis of the FLUENT software package, the 3-D wind field of an indoor ventilated environment is calculated using the Reynolds average approach, where the real wind velocity measure...

This work represents an update of the previous evaluation nuclear data on A=147 nuclides (2009Ni02). The experimental from reaction and decay studies leading to following have been reviewed: 147I, 147Xe, 147Cs, 147Ba, 147La, 147Ce, 147Pr, 147Nd, 147Pm, 147Sm, 147Eu, 147Gd, 147Tb, 147Dy, 147Ho, 147Er, 147Tm. These are presented, together with adopted level schemes their properties. 147Pm nuclide...