BACKGROUND Bile acids [BA] are usually reabsorbed by the terminal ileum, but this process is frequently abnormal in Crohn’s disease [CD]. BA malabsorption occurs, and excess colonic BA cause secretory diarrhea. Furthermore, the hormone fibroblast growth factor 19 [FGF19] is synthesized in the ileum in response to BA absorption and regulates BA synthesis. We hypothesized that reduced serum FGF19...

A Resource from Improving Chronic Illness Care This information is current as of February 2007. Does The Chronic Care Model Work? CDROM www.improvingchroniccare.org Slide 1 In this discussion of the Chronic Care Model (CCM) chronic illness is defined very broadly: any condition that requires ongoing activities and response from patients and their personal caregivers, as well as a response from ...

Background Crohn’s Disease (CD) is a chronic inflammatory bowel disease characterised by recurrent intestinal inflammation [1]. Adipose tissue has metabolic and immune functions regulated through the expression of hormones and cytokines [2,3]. Conventionally, adiposity in CD is believed to reflect disease activity, nutritional status and possibly corticosteroids. Emerging data suggests that adi...

core decompression (cd) of the femoral head is one of the effective treatments of avascular necrosis (avn), especially in the early stages of the disease. to investigate further the value of cd in treating the avn, this study was performed on patients with symptomatic avn with different etiologies who were treated with cd. this study was carried out on 25 patients (with the total number of 37 f...

Colorectal cancer is the most frequent malignant complication in patients with inflammatory bowel disease. Eighty patients with colorectal cancer complicating Crohn's disease (CD) or ulcerative colitis (UC) with median ages at diagnosis of colorectal cancer of 54.5 years and 43.0 years respectively were studied. The median duration of disease to the diagnosis of cancer was long (CD 15 years; UC...

BACKGROUND Markers that predict the occurrence of a complicated disease behavior in patients with Crohn's disease (CD) can permit a more aggressive therapeutic regimen for patients at risk. The aim of this cohort study was to test the blood levels of hemoglobin (Hgb) and hematocrit (Hct) for the prediction of complicated CD behavior and CD related surgery in an adult patient population. METHO...

Health-related quality of life (HRQoL) is recommended as one of essential parameters to evaluate treatment effect and clinical outcome in patients with Crohn's disease (CD). Recent studies reported that psychological factors might play a role in HRQoL in Western and American CD patients. Sufficient evidences in Chinese CD patients are still unavailable. This study is dedicated to investigate th...

BACKGROUND We investigated and compared the capacity of mean platelet volume (MPV) and other inflammatory markers in detecting Crohn's disease (CD) activity and differentiating CD patients from healthy controls. METHODS MPV, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and white blood cells were measured in 61 CD patients and 50 healthy subjects. Disease activity was assesse...

The presence of unique carbohydrate structures in the glycocalyx/mucous layer of the intestine may be involved in a susceptibility to celiac disease (CD) by serving as attachment sites for bacteria. This host-microbiota interaction may influence the development of CD and possibly other diseases with autoimmune components. We examined duodenal biopsies from a total of 30 children, of which 10 ha...

Background—Studies on ischemic heart disease (IHD) incidence in individuals with celiac disease (CD) are contradictory and do not take small intestinal pathology into account. Methods and Results—In this Swedish population-based cohort study, we examined the risk of IHD in patients with CD based on small intestinal histopathology. We defined IHD as death or incident disease in myocardial infarc...