Skin lesions are associated with Crohns disease (CD) in 22– 44% of patients. Metastatic Crohn's disease (MCD) is defined as granulomatous skin lesions occurring at sites separate from the gastrointestinal tract, mainly in the lower extremities and intertriginous areas.1 Genital MCD has been frequently described as refractory and usually begins as a non-healing ulcer, but can be shown as a papul...

background different clinical and epidemiological studies using dual-energy x-ray absorptiometry have shown an increased prevalence of low bone mineral density in patients with inflammatory bowel diseases.the aim of this study was to assess the correlation between bone density and the disease activity in patients with ulcerative colitis. methods in this cross-sectional study, 52 patients with u...

RATIONALE The fundamental pathogenesis of Behçet disease (BD) is still unclear and controversial. Many cases of oral aphthous ulcers and genital ulcers related to BD are reported; nevertheless, idiopathic giant esophageal ulcers related to BD are rare. A rare case for esophageal ulcers related to BD is presented. PATIENT CONCERNS In China, BD is represented with esophageal involvement which i...

HLA-B27 is a Major Histocompatibility Complex (MHC) class I molecule whose predominant function is the presentation of short 8-10 amino acid long peptides to cytotoxic CD8+T cells. HLA-B27 exhibits a strong association with a group of inflammatory arthritic diseases referred to as the spondyloarthropathies (SpAs) [1]. The SpAs are characterized by inflammation at the entheses, followed by skele...

I. Steenholdt C, Enevold C, Ainsworth MA, Brynskov J, Thomsen OO, Bendtzen K. Genetic polymorphisms of tumour necrosis factor receptor superfamily 1b and fas ligand are associated with clinical efficacy and/or acute severe infusion reactions to infliximab in Crohn's disease. Aliment Pharmacol Ther. 2012;36:650-659. II. Steenholdt C, Brynskov J, Thomsen OØ, Munck LK, Fallingborg J, Christensen L...

background systemic lupus erythematosus (sle) is an autoimmune connective-tissue disease involving multiple organs and systems. some evidence has demonstrated that disease activity could be associated with increased risk of organ damage. objectives the aim of this study was to determine the association between systemic lupus erythematosus disease activity index (sledai) scores and subclinical c...