Abstract Background Nordic walking (NW) requires more energy compared with conventional (W). However, the metabolic equation for NW has not been reported. Therefore, this study aimed to characterize responses in oxygen uptake, minute ventilation, heart rate, systolic blood pressure, and surface electromyography of upper lower limb muscles during W develop a expenditure ( E , mL·kg − 1 ·min ) NW...

OBJECTIVE The purpose of this study was to determine whether adjunctive use of a psychostimulant (mixed amphetamine salts) was safe and efficacious for treatment of symptoms of attention deficit hyperactivity disorder (ADHD) in pediatric outpatients with bipolar I or bipolar II disorder and concurrent ADHD whose manic symptoms had been stabilized through treatment with divalproex sodium. METH...

BACKGROUND Fatigue is a common symptom in stroke survivors for which there is currently no proven therapy. Modafinil is a wakefulness-promoting agent with established benefits in other disease models. We aim to test if modafinil will improve patient's self-reported fatigue scores when compared to placebo and if therapy results in increased quality of life. METHODS/DESIGN MIDAS is a phase II, ...

Background Cardiovascular diseases are the major cause of hospitalization. Dietary salt restriction is indicated as part clinical treatment, however, it not always well accepted by patients, resulting in low food intake and malnutrition. Objective To compare acceptance a low-sodium diet cooked with standard cardiac inpatients. Methods A randomized controlled crossover trial patients prescriptio...

OBJECTIVE To evaluate the characteristics of the design, analysis, and reporting of crossover trials for inclusion in a meta-analysis of treatment for primary open-angle glaucoma and to provide empirical evidence to inform the development of tools to assess the validity of the results from crossover trials and reporting guidelines. METHODS We searched MEDLINE, EMBASE, and Cochrane's CENTRAL r...

Multi-trial Lin-Kernighan-Helsgaun 2 (LKH-2) is widely considered to be the best Interated Local Search heuristic for the Traveling Salesman Problem (TSP) and has found the best-known solutions to a large number of benchmark problems. Although LKH-2 performs exceptionally well on most instances, it is known to have difficulty on clustered instances of the TSP. Generalized Partition Crossover (G...

The effect of treatment with percutaneous E(2) (100 μg/24 h) during 2 weeks perimenstrually on the number and severity of menstrual migraine attacks was studied in 27 women in a randomized, placebo-controlled, double-blind, crossover trial. We were not able to demonstrate any difference between E(2) supplementation and placebo on the number or severity of migraine attacks, but both regimens sho...

The effect of sodium valproate 1200 mg daily on the disability of Parkinsonism and on levodopa-induced dyskinesia was assessed in a double-blind crossover trial with matched placebo in 12 patients with Parkinson's disease. No objective change in the severity of Parkinsonism or dyskinesias was noted. However, six out of nine patients who completed the trial noted a slight to moderate improvement...

A double-blind crossover trial between diclofenac sodium and placebo was carried out in 32 hospitalized patients who were thought to be stabilized on concurrent anticoagulant therapy with acenocoumarol. The object of the trial was to investigate any possible interaction between diclofenac and anticoagulant by monitoring prothrombin times daily through the four week period. No statistically sign...

The stepped-wedge cluster randomised trial (SW-CRT) is a novel research study design that is increasingly being used in the evaluation of service delivery type interventions. The SW-CRT is a type of randomised trial in which clusters are randomised to a date at which they initiate the intervention under evaluation. The design involves random and sequential crossover of clusters from control to ...