New polynitrides containing metastable forms of nitrogen are actively investigated as potential high-energy-density materials. Using a structure search method based on the CALYPSO methodology, we investigated the stable stoichiometries and structures of cesium polynitrides at high pressures. Along with the CsN3, we identified five new stoichiometric compounds (Cs3N, Cs2N, CsN, CsN2, and CsN5) w...

Selective signatures in whole genome can help us understand the mechanisms of selection and target causal variants for breeding program. In present study, we performed Extended Haplotype Homozygosity (EHH) tests to identify significant core regions harboring such signals in Chinese Holstein, and then verified the biological significance of these identified regions based on commonly-used bioinfo...

The natural flavone acacetin inhibits several voltage-gated potassium currents in atrial myocytes, and has anti-atrial fibrillation (AF) effect in experimental AF models. The present study investigates whether acacetin inhibits the Ca2+-activated potassium (KCa) currents, including small conductance (SKCa1, SKCa2, and SKCa3), intermediate conductance (IKCa), and large-conductance (BKCa) channel...

The reaction of CsN3 with GaS and S at elevated temperatures results in Cs2Ga2S5. Its crystal structure was determined from single-crystal X-ray diffraction data. The colorless solid crystallizes in space group C2/c (no. 15) with V = 1073.3(4) Å(3) and Z = 4. Cs2Ga2S5 is the first compound that features one-dimensional chains ∞(1)([Ga2S3(S2)(2-)] of edge- and corner-sharing GaS4 tetrahedra. The...

Myeloid leukemia factor 1 (MLF1) stabilizes the activity of the tumor suppressor p53 by suppressing its E3 ubiquitin ligase, COP1, through a third component of the COP9 signalosome (CSN3). However, little is known about how MLF1 functions upstream of the CSN3-COP1-p53 pathway and how its deregulation by the formation of the fusion protein nucleophosmin (NPM)-MLF1, generated by t(3;5)(q25.1;q34)...

We prove a uniform bound on the topological Turán number of an arbitrary two-dimensional simplicial complex S: any n vertices with at least CSn3−1/5 facets contains homeomorph S, where CS > 0 is constant depending S alone. This result, analogue classical one-dimensonal result Mader, sheds some light old problem Linial from 2006.

BACKGROUND AND PURPOSE The Slo3 (KCa 5.1) channel is a major component of mammalian KSper (sperm potassium conductance) channels and inhibition of these channels by quinine and barium alters sperm motility. The aim of this investigation was to determine the mechanism by which these drugs inhibit Slo3 channels. EXPERIMENTAL APPROACH Mouse (m) Slo3 (KCa 5.1) channels or mutant forms were expres...

Abstract The aim was to study the dependence of single-nucleotide polymorphism CSN3 gene on amino acid and mineral composition milk Holstein cows. object research is cows (n=100; age - 4-5 years). elemental estimated according 25 chemical elements (Al, As, B, Ca, Cd, Co, Cr, Cu, Fe, I, K, Li, Mg, Mn, Na, Ni, P, Pb, Se, Si, Sn, Hg, Sr, V, Zn) by ICP AES MS. (arginine, tyrosine, phenylalanine, hi...