نتایج جستجو برای: ctrp 3
تعداد نتایج: 1811344 فیلتر نتایج به سال:
The consistency of in vitro drug sensitivity data is of key importance for cancer pharmacogenomics. Previous attempts to correlate drug sensitivities from the large pharmacogenomics databases, such as the Cancer Cell Line Encyclopedia (CCLE) and the Genomics of Drug Sensitivity in Cancer (GDSC), have produced discordant results. We developed a new drug sensitivity metric, the area under the dos...
Increasing evidence indicates that adipose tissue-originated cytokines mediate communication between obesity-related exogenous molecules and the molecular events that initiate the metabolic syndrome and the inflammatory responses in the cardiovascular system (CVS). Adipose tissue-derived cytokines including the C1q/tumor necrosis factor-related proteins (CTRPs), a 15-member family of novel adip...
The high rate of clinical response to protein-kinase-targeting drugs matched to cancer patients with specific genomic alterations has prompted efforts to use cancer cell line (CCL) profiling to identify additional biomarkers of small-molecule sensitivities. We have quantitatively measured the sensitivity of 242 genomically characterized CCLs to an Informer Set of 354 small molecules that target...
Security problems in collaborative work between multiple agencies are less well understood than those in the business and defence worlds. We develop a perspective for policies and models that is task-based on a need-toknow basis. These policies are represented by two protocols, the first CTCP (Collaboration Task-based Creation Protocol) dealing with negotiation, decision and agreement between t...
Abstract Background Predicting the drug response of cancer diseases through cellular perturbation signatures under action specific compounds is very important in personalized medicine. In process testing responses to cancer, traditional experimental methods have been greatly hampered by cost and sample size. At present, public availability large amounts gene expression data makes it a challengi...
CTRP3, discovered as novel adipokines, is a member of the C1q tumor necrosis factor (TNF) related protein (CTRP) super-family. CTRP3 is found to function as adipokines that display diverse biological activities in metabolic and cardiovascular diseases. Recent study demonstrated that CTRP3 was protective against pathological cardiac remodeling in mice. Nevertheless, the effect of CTRP3 on vascul...
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