The development of circuit devices can involve both physical and computer simulation experiments. Here, we discuss statistical solutions for both design of the physical experiment and optimization for the calibration of the computer model. In both cases, we can view the problem as one of optimization, and we rely upon treed Gaussian processes to model the data and guide our design choices.

In this study, an integrated microfluidic device was developed for drug permeability assays with real-time online detection by a directly coupled mass spectrometer. The integrated microfluidic device contained two independent channels sandwiched by a semipermeable polycarbonate membrane for cell culture, and micro solid-phase extraction (SPE) columns for sample clean-up and concentration prior ...

The design of an experiment can greatly affect its potential to produce statistically conclusive results. In this paper, we offer a method for increasing the statistical informativeness of an experiment through the use of adaptive design optimization. The problem to be solved in adaptive design optimization is identifying an experimental design under which one can infer the underlying model and...

introduction: retinoic acid (ra), one of the syntetic vitamin a derivatives which has been frequently used as a drug to treat face acne, is known to have specific side effects on the testis, liver, and spleen, it is also known as an oxidative agent in high doses. therefore, we have tried to find a compound which would decrease its side effects. curcumin which is found in the rhizome of turmeric...

in order to study of nutritional role of silicon nano-particles on physiological characteristics of minituber potato production an experiment was carried out as  factorial based on randomized complete blocks design with three replications in hydroponic culture at ferdowsi university, mashhad. treatments were included particle size of sodium silicate (nano and micro) and concentrations in levels...

the multivariate exponentially weighted moving average (mewma) control chart is one of the best statistical control chart that are usually used to detect simultaneous small deviations on the mean of more than one cross-correlated quality characteristics. the economic design of mewma control charts involves solving a combinatorial optimization model that is composed of a nonlinear cost function ...

Curcumin, a yellow polyphenol derived from the turmeric Curcuma longa, has been associated with a diverse therapeutic potential including anti-inflammatory, antioxidant, antiviral, and anticancer properties. However, the poor aqueous solubility and low bioavailability of curcumin have limited its potential when administrated orally. In this study, curcumin was encapsulated in a series of novel ...

Objective(s): Biological applications of gold nanoparticles have limitations because of the toxic chemicals used in their synthesis. Curcumin can be used as reducing as well as capping agent in synthesis of GNPs to eliminate the cytotoxicity. Conjugation of curcumin to gold also helps in increasing its solubility and bioavailability. Materials and Methods: Here we report synthesis of gold nanop...