Primary systemic amyloidosis is a rare disorder characterized by multisystemic homogenous hyaline amyloid material. We report a case of 68 years old male presented with generalized weakness, fatigue, anorexia and impaired taste sensation. Muco-cutaneous lesions like, macroglossia with bullous haemorrhagic lesions, peri-orbital purpura, and nail changes were present. He had no cardiomegaly, hepa...

Two major types of amyloidosis are primary amyloidosis or amyloid light chain amyloidosis and secondary amyloidosis. Although amyloidosis involves a variety of organ systems including skin, the occurrence of bullous skin lesions is rare. Little is known about the mechanism of blister formation. These blisters are often hemorrhagic and typically occur in the oral mucosa. Only a few case reports ...

The purpose of this study was to apply functionalized magnetic nanoparticles for the treatment amyloidosis, a disease characterized by accumulation aberrant protein forms with an insoluble amyloid structure. dissolution and clearance these extremely stable fibrils from lesions is very complicated. For purpose, we examined possibility using that generate heat in external alternating field freque...

© 2017 Indian Dermatology Online Journal | Published by Wolters Kluwer Medknow A 40‐year‐old male presented with a 6‐month history of a gradually progressing, painless, firm, 10 × 8 mm erythematous nodule on his nose [Figure 1]. Skin biopsy showed nodular deposition of eosinophilic, acellular, amyloid material in the entire dermis, which was surrounded by focal plasma cell infiltrate [Figure 2]...

INTRODUCTION Amyloidosis is defined as extracellular deposits of heterogenic, misfolded proteins, amyloid fibrils, in various tissues. The aim of our study was to review the literature and to evaluate the risk of developing systemic amyloidosis (SA) and the risk of local recurrence of primary localised cutaneous amyloidosis (PLCA). The method of treatment was compared to the risk of local recur...