BACKGROUND Primary cutaneous B-cell lymphoma typically localizes to the skin, and dissemination to internal organs is rare. Lymphomatous involvement of the breasts is also rare. We describe the clinical and radiological findings of an unusual case of primary cutaneous B-cell lymphoma presenting as an isolated breast mass without associated skin changes. CASE PRESENTATION The patient was a 55-...

BACKGROUND Primary cutaneous T-cell lymphomas constitute a heterogeneous and rare group of diseases with regional particularities in Latin America. OBJECTIVE To determine the clinicopathological features, relative frequency and survival among patients from a Peruvian institution. METHODS Primary cutaneous T-cell lymphomas were defined based on the absence of extracutaneous disease at diagno...

Intravascular large B-cell Lymphoma (IVLBCL) is a rare subtype of extranodal non-Hodgkin’s lymphoma that challenging to diagnose and has poor prognosis. Here, we describe two patients newly diagnosed with IVLBCL at our institution: an African man hemophagocytic-syndrome-associated Italian woman cutaneous variant IVLBCL. They presented very different clinical manifestations. Both cases were in t...

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Cutaneous T cell lymphoma (CTCL) is a broad diagnostic group encompassing a spectrum of diseases with variable clinical presentations. Histologic and immunohistochemical confirmation is needed to establish a precise diagnosis. Primary cutaneous CD 30+ anaplastic large cell lymphoma, a definite variety of CTCL, presenting as a non-healing ulcer is presented here which, needed multimodality appro...

BACKGROUND Primary cutaneous B-cell lymphoma manifested by anetoderma has been reported in 7 cases. In all, the secondary anetoderma developed in lesions of marginal-zone lymphoma or posttransplant lymphoproliferative disorder resembling marginal-zone lymphoma. The mechanisms underlying the destruction of elastic tissue in anetoderma are unclear. However, there is growing evidence linking prima...

BACKGROUND Vorinostat (suberoylanilide hydroxamic acid, SAHA), an inhibitor of class I and II histone deacetylases, has been approved for the treatment of cutaneous T-cell lymphoma. In spite of emerging information on the effect of vorinostat in many types of cancer, little is yet known about this drug's mechanism of action, which is essential for its proper use in combination therapy. We inves...

Discussion | In 1995, Benchikhi et al4 reported the first case of cutaneous B-cell lymphoma associated with follicular mucinosis in a patient with bone-marrow and peripheral blood infiltration.4We report the first caseof primary cutaneous follicle center lymphoma with follicular mucinosis. Cutaneous lymphomascanusuallybedistinguishedbyarchitectural features, where most atypical lichenoid infilt...

NPM-ALK chimeric transcripts, encoded by the t(2;5), lead to an aberrant expression of ALK by CD30+ systemic lymphomas. To determine if t(2;5) is involved in cutaneous lymphoproliferative disorders, we studied 37 CD30+ cutaneous lymphoproliferations, 27 mycosis fungoides (MF), and 16 benign inflammatory disorders (BID). NPM-ALK transcripts were detected by nested reverse transcription-polymeras...

Jessner’s lymphocytic infi ltrate of the skin is a rare, benign cutaneous disorder. Diffi culty arises in differentiating it from cutaneous lymphoma on histology, thus requiring immunophenotying, however the literature lacks reports demonstrating malignant transformation or dual pathology. We present a case of Jessner’s lymphocytic infi ltrate who later presented with areas of cutaneous B-cell ...