نتایج جستجو برای: cxcl5
تعداد نتایج: 442 فیلتر نتایج به سال:
During metastasis, host cells are recruited to disseminated tumor cells to form specialized microenvironments ("niches") that promote metastatic progression, but the mechanisms guiding the assembly of these niches are largely unknown. Tumor cells may autonomously recruit host cells or, alternatively, host cell-to-host cell interactions may guide the formation of these prometastatic microenviron...
Myeloid-derived suppressor cells (MDSCs) play an important role in tumor immune escape. Recent studies have shown that MDSCs contribute to progression under psychological stress, but the underlying mechanism of mobilization and recruitment remains largely unknown. In present study, a chronic restraint stress paradigm was applied H22 hepatocellular carcinoma (HCC) bearing mice mimic stress. We o...
Interleukin-6 signaling via its soluble receptor (sIL-6R) differentially regulates inflammatory chemokine expression and leukocyte apoptosis to coordinate transition from neutrophil to mononuclear cell infiltration. sIL-6R activities may, however, be influenced in vivo by the occurrence of two sIL-6R isoforms that are released as a consequence of differential mRNA splicing (DS) or proteolytic c...
AIM To determine if exacerbation of pre-existing chronic colitis in Winnie (Muc2 mutant) mice induces colonic dysplasia. METHODS Winnie mice and C57BL6 as a genotype control, were administered 1% w/v dextran sulphate sodium (DSS) orally, followed by drinking water alone in week-long cycles for a total of three cycles. After the third cycle, mice were killed and colonic tissue collected for hi...
Plasminogen activating inhibitor-1 (PAI-1) is classically known as an angiogenesis promoting factor that associated with poor clinical outcomes in various cancers, including skin cancer such cutaneous melanomas. Cutaneous angiosarcoma (CAS) a vascular tumor histologically characterized by detachment of endothelial cell-derived cells. Since CAS expresses multiple angiogenic growth factors and ha...
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