We introduce the Calabi-Yau (CY) objects in a Hom-finite Krull-Schmidt triangulated k-category, and notice that the structure of the minimal, consequently all the CY objects, can be described. The relation between indecomposable CY objects and Auslander-Reiten triangles is provided. Finally we classify all the CY modules of selfinjective Nakayama algebras, determining this way the self-injectiv...

Abstract. In this paper we generalized the variational formulas for the determinants of the Laplacians on functions of CY metrics to forms of type (0,q) on CY manifolds. We also computed the Ray Singer Analytic torsion on CY manifolds we proved that it is bounded by a constant. In case of even dimensional CY manifolds the Ray Singer Analytic torsion is zero. The interesting case is the odd dime...

A 17-year-old man with mediastinal seminoma was treated with chemotherapy and mediastinal irradiation therapy. Then he received high-dose chemotherapy containing cyclophosphamide (CY) followed by autologous peripheral blood stem cell transplantation. He suffered from CY-induced cardiomyopathy beginning six days after the administration of high-dose CY. The predictable factors associated with th...

Recent observations demonstrated that fluconazole plus cyclosporine (Cy) synergistically killed Candida albicans in vitro. This combination was tested in rats with C. albicans experimental endocarditis. The MICs of fluconazole and Cy for the test organism were 0.25 and >10 mg/liter, respectively. Rats were treated for 5 days with either Cy, amphotericin B, fluconazole, or fluconazole-Cy. Althou...

Observed only after administration of high doses, cardiotoxicity is the dose-limiting effect of cyclophosphamide (CY). We investigated the poorly understood cardiotoxic mechanisms of high-dose CY. A rat cardiac myocardial cell line, H9c2, was exposed to CY metabolized by S9 fraction of rat liver homogenate mixed with co-factors (CYS9). Cytotoxicity was then evaluated by 3-(4,5-dimethyl-2-thiazo...

Cyst expansion in polycystic kidney disease (PKD) results in localized hypoxia in the kidney that may activate hypoxia-inducible factor-1α (HIF-1α). HIF-1α and autophagy, a form of programmed cell repair, are induced by hypoxia. The purposes were to determine HIF-1α expression and autophagy in rat and mouse models of PKD. HIF-1α was detected by electrochemiluminescence. Autophagy was visualized...

In this paper, we introduce a variation of the wellstudied Yao graphs. Given a set of points S ⊂ R and an angle 0 < θ ≤ 2π, we define the continuous Yao graph cY (θ) with vertex set S and angle θ as follows. For each p, q ∈ S, we add an edge from p to q in cY (θ) if there exists a cone with apex p and aperture θ such that q is the closest point to p inside this cone. We study the spanning ratio...

Abstract In this note, we prove the semiampleness conjecture for Kawamata log terminal Calabi–Yau (CY) surface pairs over an excellent base ring. As applications, deduce that generalized abundance and Serrano’s hold surfaces. Finally, study CY threefolds a mixed characteristic DVR.

The influence of tumor size on the ability of S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-2721) or misonidazole (MISO) to alter cyclophosphamide (CY) antitumor activity was investigated, using a chemically induced fibrosarcoma (FSA) and a spontaneous fibrosarcoma (NFSA) in C3Hf/Kam mice. Tumors were of two sizes at the time of treatment, 8-mm leg tumors and 4-day-old micrometastases i...

Previous studies demonstrated that single doses of systemic cyclophosphamide (CY) as low as 0.5 mg/kg are effective in preventing bladder tumor implantation in a rat model. In an effort to determine if the urinary bladder represents a unique site of CY activity, a series of experiments were performed to define the mechanism by which low-dose CY prevents bladder tumor implantation. Potential sit...