INTRODUCTION CyberKnife® radiation is an effective treatment for unresectable skull base tumors because it can deliver a highly conformational dose distribution to the complex shapes of tumor extensions. There have been few reports of severe complications with this treatment. This is the first published case report to our knowledge of cerebrospinal fluid leakage induced by CyberKnife® radiother...

OBJECTIVES To evaluate efficacy, patient tolerance, and adverse effects of CyberKnife radiosurgery for the treatment of intraocular and periocular lymphoma. METHODS Retrospective case series of 13 patients who underwent CyberKnife radiosurgery was conducted. RESULTS Fourteen eyes of 13 patients were included. The tissue location of the lymphoma was orbit (7 eyes), conjunctiva (3 eyes), chor...

We evaluated 5-year follow-up of stereotactic body radiation therapy (SBRT) with Cyberknife for prostate cancer patients. Forty-five men with prostate adenocarcinoma who received SBRT using Cyberknife from May 2006 to November 2012 were enrolled in this study. They were prostate cancer patients with old age and medical comorbidities who received a total of 36 Gy to the prostate in 5 fractions w...

PURPOSE The first stereotactic arrhythmia radioablation (STAR) of ventricular tachycardia (VT) was delivered at Stanford on a robotic radiosurgery system (CyberKnife® G4) in 2012. The results warranted further investigation of this treatment. Here we compare dosimetrically three possible treatment delivery platforms for STAR. METHODS The anatomy and target volume of the first treated patient ...

PURPOSE The purpose of this work is to assess the variation in performance of various commercially available dosimetry diodes for quantitative small field dosimetry, specifically by intercomparing measurements of SRS cone factors. METHODS Measurements were made in 6 MV photon beams with fixed SRS cones for two accelerator-based SRS systems: a Varian Clinac iX (Varian/Zmed cones) at 600 MU/min...

BACKGROUND The first-line treatment of a pelvic recurrence in a previously irradiated area is surgery. Unfortunately, few patients are deemed operable, often due to the location of the recurrence, usually too close to the iliac vessels, or the associated surgical morbidity. The objective of this study is to test the viability of robotic image-guided radiotherapy as an alternative treatment in i...

PURPOSE Stereotactic body radiotherapy (SBRT) takes advantage of low α/β ratio of prostate cancer to deliver a large dose in few fractions. We examined clinical outcomes of SBRT using CyberKnife for the treatment of low- and intermediate-risk prostate cancer. MATERIALS AND METHODS This study was based on a retrospective analysis of the 33 patients treated with SBRT using CyberKnife for locali...

OBJECTIVE To present our experience with placing endovascular coils in pulmonary arteries used as a fiducial marker for CyberKnife therapy and to describe the technical details and complications of the procedure. MATERIALS AND METHODS Between June 2005 and September 2013, 163 patients with primary or secondary lung malignancies, referred for fiducial placement for stereotactic radiosurgery, w...

Cyberknife Radiosurgery – Overview Cyberknife technology is based on radiosurgical principles that have been in clinical practice for 30 years. Radiosurgery is the precise application of a high (tumour-destructing) dose of radiation in a precisely defined target volume, while protecting the surrounding healthy tissue. During radiosurgery, many radiation beams from different directions intersect...

PURPOSE To investigate the efficacy of the integration of functional magnetic resonance imaging and diffusion-tensor imaging tractography data into CyberKnife radiosurgery for intracranial tumor management. MATERIALS AND METHODS Functional neuroimaging, anatomical magnetic resonance imaging, and computed tomography images of patients with brain lesions in critical areas were acquired before r...