Transcriptional activation by CLOCK-CYCLE (CLK-CYC) heterodimers and repression by PERIOD-TIMELESS (PER-TIM) heterodimers are essential for circadian oscillator function in Drosophila. PER-TIM was previously found to interact with CLK-CYC to repress transcription, and here we show that this interaction inhibits binding of CLK-CYC to E-box regulatory elements in vivo. Coincident with the interac...

BACKGROUND Cystatin C (CyC) is more sensitive than serum creatinine (sCr) to rapidly detect acute changes in renal function. METHODS AND RESULTS We measured CyC together with sCr in 410 consecutive patients with chronic kidney disease undergoing either coronary and/or peripheral angiography and/or angioplasty. sCr was assessed at baseline and 24 and 48 hours after contrast media exposure. CyC...

CycQL is an Apache Jena/ARQ based SPARQL adapter for OpenCyc 4.0. It enables the Cyc inference engine to be used with Semantic Web tools via a SPARQL endpoint. Cyc achieves scalability and optimizes inference by restricting the search space to a relevant subset of microtheories. With this adapter, Cyc microtheories are identified with RDF named graphs. This paper demonstrates how greater effici...

The ancestor of tomato underwent whole genome triplication ca. 71 Myr ago followed by widespread gene loss. However, few of the triplicated genes are retained in modern day tomato including lycopene beta cyclase that mediates conversion of lycopene to β-carotene. The fruit specific β-carotene formation is mediated by a chromoplast-specific paralog of lycopene beta cyclase (CYC-B) gene. Presentl...

The purpose of this course-based inquiry was to gain insight into how child and youth care (CYC) students apply theoretical frameworks in their connection-building efforts with children youth. A qualitative research design chosen for the capturing lived experiences CYC student participants. findings presented study revealed three overarching themes: a) provides pathways understanding, b) all ab...

UNLABELLED Separate authors have reported that knee extension dominates power production during submaximal cycling (SUB(cyc)) and hip extension is the dominant action during maximal cycling (MAX(cyc)). Changes in joint-specific powers across broad ranges of net cycling powers (P(net)) within one group of cyclists have not been reported. PURPOSE Our purpose was to determine the extent to which...

Background—Cystatin C (CyC) is more sensitive than serum creatinine (sCr) to rapidly detect acute changes in renal function. Methods and Results—We measured CyC together with sCr in 410 consecutive patients with chronic kidney disease undergoing either coronary and/or peripheral angiography and/or angioplasty. sCr was assessed at baseline and 24 and 48 hours after contrast media exposure. CyC w...

The Drosophila circadian clock keeps time via transcriptional feedback loops. These feedback loops are initiated by CLOCK-CYCLE (CLK-CYC) heterodimers, which activate transcription of genes encoding the feedback repressors PERIOD and TIMELESS. Circadian clocks normally operate in ∼150 brain pacemaker neurons and in many peripheral tissues in the head and body, but can also be induced by express...

OBJECTIVE To review the development, histological type and outcome of a cohort of patients with lupus nephritis who were managed and followed up by the specialist Bloomsbury Rheumatology Unit between 1977 and 1999. PATIENTS AND METHODS Seventy-eight of the 280 (28%) patients with systemic lupus erythematosus (SLE) developed nephritis. Occurrence of end stage renal disease (ESRD) according to ...

results there was a significant increase (p < 0.05) in leptin levels on day 14 (12.75 + 5.8 ng/ml) and day 21 (12.91 + 3.2 ng/ml) for age group 18-30 years compared to day 14 (11.60 + 3.2 ng/ml) and day 21 (11.60 + 3.2 ng/ml) for age group 31-40 years. leptin was positively correlated with fsh on day 14, with lh on day 7 and day 21; likewise, with progesterone on day 21 and day 28 and with estr...