Stability studies play a critical role in assuring product quality at all points in the vaccine life cycle. These studies used to determine vaccine expiry date and vaccine efficacy. Accelerated stability and long term stability study performed for three batches of trivalent oral poliomyelitis vaccine (OPV) and three batches of monovalent OPV (type1) manufactured by Razi institute. After samplin...

stability studies play a critical role in assuring product quality at all points in the vaccine life cycle. these studies used to determine vaccine expiry date and vaccine efficacy. accelerated stability and long term stability study performed for three batches of trivalent oral poliomyelitis vaccine (opv) and three batches of monovalent opv (type1) manufactured by razi institute. after samplin...

Mathematical techniques have provided tools to quantify the stability of rhythmic movements of humans and machines as well as mathematical models. One archetypal example is the use of Floquet multipliers: assuming periodic motion to be a limit-cycle of a nonlinear oscillator, local stability has been assessed by evaluating the rate of convergence to the limit-cycle. However, the accuracy of the...

Progression through the cell cycle in somatic eukaryotic cells is regulated by variations in the levels of cyclin proteins. These protein levels are in turn regulated by cyclical oscillations in their mRNA levels. We show here that regulation of RNA stability plays a role in the mechanisms underlying cell cycle progression. Both cyclin A and B1 messages are expressed at high levels in G2-M and ...

[1] Using a new reanalysis data set, the seasonal cycle of the midlatitude tropospheric static stability is examined. Dry and moist static stability measures are analyzed as a function of latitude, longitude, and season. It is shown that in both the Northern (NH) and Southern Hemispheres (SH), dry and moist static stability averaged over the midlatitudes maximizes in December–February. Examinin...

p18 is a member of the INK4 family of proteins that regulate the G1 to S cell cycle transition by binding to and inhibiting the pRb kinase activity of cyclindependent kinases 4 and 6. The p16 member of the INK4 protein family is altered in a variety of cancers and structure-function studies of the INK4 proteins reveal that the vast majority of missense tumor-derived p16 mutations reduce protein...

p18(INK4c) is a member of the INK4 family of proteins that regulate the G(1) to S cell cycle transition by binding to and inhibiting the pRb kinase activity of cyclin-dependent kinases 4 and 6. The p16(INK4a) member of the INK4 protein family is altered in a variety of cancers and structure-function studies of the INK4 proteins reveal that the vast majority of missense tumor-derived p16(INK4a) ...

We present a competition model of tumor growth that includes the immune system response and a cycle-phase-specific drug. The model considers three populations: Immune system, population of tumor cells during interphase and population of tumor during mitosis. Delay differential equations are used to model the system to take into account the phases of the cell cycle. We analyze the stability of t...

By modulating engine valves to reinduct hot exhaust gas together with air and fuel, a clean and efficient form of autoignition can be created. Control of this combustion process, known as homogeneous charge compression ignition (HCCI), requires not only precise valve control but also a combustion control strategy that accounts for the cycle-to-cycle coupling through the exhaust. This paper outl...