نتایج جستجو برای: cyclooxygenase cox

تعداد نتایج: 58101  

Journal: :African Journal of Pharmacy and Pharmacology 2023

Cyclooxygenase 2 (COX-2) is involved in the production of prostaglandins that sustain inflammatory process. Inflammatory cells release a number reactive species. Furthermore, oxygen species can initiate intracellular signaling cascades and enhance expression pro-inflammatory genes. The objective was to study cyclooxygenase protein denaturation inhibition antioxidant activity ten extracts from f...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه ارومیه - دانشکده علوم 1393

یکی از پروتئین های درگیر با سرطان و استرس، گیرنده های بتا آدرنرژیک اند. پروتئین cox-2 نیز فرمی از آنزیم سیکلواکسیژناز (cyclooxygenase) است که توسط فاکتورهای متعددی از جمله التهاب القا شده و با تومورزایی همراه است. فعالیت درمانی بلوکه کننده های بتا مانند پروپرانولول و مهارکننده ی انتخابی cox-2 مانند سلکوکسیب (celecoxib) به ترتیب به بلوکه کردن گیرنده های بتا آدرنرژیک و مهار آنزیم cox-2 نسبت داده ...

2015
Blerina Ahmetaj-Shala Nicholas S. Kirkby Rebecca Knowles Malak Al’Yamani Sarah Mazi Zhen Wang Arthur T. Tucker Louise Mackenzie Paul C. J. Armstrong Rolf M. Nüsing James A. P. Tomlinson Timothy D. Warner James Leiper Jane A. Mitchell

C yclooxygenase (COX) catalyzes the conversion of ara-chidonic acid to prostaglandin H 2 , which is then further metabolized by downstream synthase enzymes to a range of eicosanoids. COX is expressed in 2 isoforms, constitutive COX-1 and inducible COX-2. Nonsteroidal anti-inflamma-tory drugs (NSAIDs) are widely used to treat inflammation and pain and show potential to prevent cancer. COX-2 is t...

Journal: :The Kobe journal of medical sciences 2007
Takeshi Sugimoto Tamio Koizumi Tamotsu Sudo Satoshi Yamaguchi Atsumi Kojima Shunichi Kumagai Ryuichirou Nishimura

OBJECTIVES Cyclooxygenase-2 (Cox-2) is known to be associated with tumorigenesis in many cancers including endometrial cancer, while there is substantial evidence for the tumorigenicity of cyclooxygenase-1 (Cox-1). However, little is known about the involvement of Cox-1 in the development of endometrial cancer. The aim of this study was to determine whether cyclooxygenase-1 or -2 (Cox-1, Cox-2)...

Journal: :Proceedings for Annual Meeting of The Japanese Pharmacological Society 2018

Journal: :Journal of Applied Biological Chemistry 2023

A new series of peptide-like derivatives containing different aromatic amino acids andpossessing pharmacophores of COX-2 inhibitors as SO2Me or N3 attached to the para positionof an end phenyl ring was synthesized for evaluation as selective cyclooxygenase-2 (COX-2)inhibitors. The synthetic reactions were based on the solid phase peptide synthesis methodusing Wang resin. One of the analogues, i...

B. Shivakumar, k.m. Manjanna,

Arthritis refers to different medical conditions associated with disorder of the primary structures that determine joint functions such as bones, cartilage and synovial membranes. Drug discovery and delivery to retard the degeneration of joint tissues are challenging. Current treatments of different arthritis involves administration of ideal non-steroidal anti-inflammatory drugs (NSAIDs) but ar...

Journal: :Anesthesiology 2003
Ian Gilron Brian Milne Murray Hong

NONSTEROIDAL antiinflammatory drugs (NSAIDs) have been shown to reduce pain and opioid consumption and often accelerate recovery after surgery. However, perioperative inhibition of prostaglandin synthesis by NSAIDs may cause complications, including renal injury, gastric ulceration, and bleeding. Recent molecular studies distinguishing between constitutive cyclooxygenase-1 (COX-1) and inflammat...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998
R N Dubois S B Abramson L Crofford R A Gupta L S Simon L B Van De Putte P E Lipsky

Cyclooxygenase (COX), the key enzyme required for the conversion of arachidonic acid to prostaglandins was first identified over 20 years ago. Drugs, like aspirin, that inhibit cyclooxygenase activity have been available to the public for about 100 years. In the past decade, however, more progress has been made in understanding the role of cyclooxygenase enzymes in biology and disease than at a...

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