BACKGROUND Conventional meta-analyses and randomized controlled trials have shown inconsistent results regarding the efficacy of immunosuppressants for pediatric steroid-resistant nephrotic syndrome (SRNS). OBJECTIVE To conduct a network meta-analysis aimed at evaluating the efficacy and safety of available immunosuppressive agents in pediatric patients with SRNS. STUDY METHODS MEDLINE, the...

Corticosteroids cause an enhanced return of granulopoiesis as measured by in vitro growth of granulocytic progenitor cells (CFU-C) in mice treated with cyclophosphamide. After methylprednisolone and cyclophosphamide, a greater than threefold increase in marrow CFU-C was measured on day 4 compared to mice given cyclophosphamide alone (29,700+/-200 vs. 8,400+/-700/humerus). The accelerated return...

BACKGROUND Cyclophosphamide is an alkylating agent widely used in antineoplastic and immunosuppressive therapies. Symptomatic hyponatremia can be a rare but life-threatening complication in patients treated with cyclophosphamide. CASE PRESENTATIONS We report 2 patients who presented with severe acute hyponatremic encephalopathy after receiving their first cycles of a low-dose cyclophosphamide...

BACKGROUND Canova activates macrophages and indirectly induces lymphocyte proliferation. Here we evaluated the effects of Canova in cyclophosphamide-treated non-human primates. METHODS Twelve Cebus apella were evaluated. Four animals were treated with Canova only. Eight animals were treated with two doses of cyclophosphamide (50 mg/kg) and four of these animals received Canova. Body weight, b...

BACKGROUND In minimal change nephrotic syndrome (MNCS), the most common primary nephrotic syndrome in children, approximately 95% of cases show excellent responses to steroid therapy. However, responding patients may become steroid dependent and experience serious side effects. Although oral cyclophosphamide has been recommended in these patients, long-term side effects such as gonadal toxicity...

We deal with various strains of Lactobacillus that can maintain the intestinal microbiome rats treated cyclophosphamide, an anticancer agent (chemotherapy). use MiSeq and types statistical tests to prove cyclophosphamide in alters microbiome, favoring growth fungi are extremely harmful metabolism. On contrary, when 3L is administered together we preserved by having a much better

The pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide/aldophosphamide has been evaluated in 12 patients with metastatic breast cancer undergoing high-dose chemotherapy followed by bone marrow transplantation. Each patient received an initial dose of 4 g/m2 of cyclophosphamide over 90 min to prime peripheral blood progenitor cells (the first course), and 3 weeks later, 6 g/m2 of...

Cyclophosphamide is an anticancer drug with immunosuppressive activities. Considering various reports on the possible antioxidant/protective functions of ascorbic acid, it is aimed at to explore the modulatory effect of ascorbic acid on therapeutic efficacy as well as mutagenic potentials of cyclophosphamide in the same tumor bearing mice. Swiss albino mice with ascites Dalton’s lymphoma were u...

BACKGROUND Primordial follicular depletion has thought to be a common adverse effect of chemotherapy especially for female of reproductive age. The study aimed to evaluate the protective effect of rapamycin on the primordial follicles and its potential mechanism for patients receiving chemotherapy. METHODS 8-week old BALB/c female mice were randomly assigned into four groups (control; rapamyc...

Cyclophosphamide is the most commonly used alkylating agent for anti cancer chemotherapy and immunosuppression. Halothane and sevoflurane are volatile anesthetics and halothane has been demonstrated to enhance cyclophosphamide toxicity. However, the interaction between sevoflurane and cyclophosphamide has not yet been investigated. We evaluated the effects of cyclophosphamide on myocardial depr...