Immunosuppressive drugs are now unavoidibly used after the transpantation of liver,heart and bone marrow, as well as in certain autoimmune diseases.among these agents,cyclosporine-A (CYA) is one of the most effective Immunosuppressants which is widely used.but as any Immunosuppressive agent,the use of CYA is not without harmful side effects.neurotoxin,nephrotoxic and hepatotoxic complications,m...

conclusions cyclosporine and tacrolimus reduce proteinuria and serum creatinine after 6 months. nonetheless, tacrolimus reduces urea and cyclosporine increases it. however, since the prevalence of the side effects of both drugs is similar, tacrolimus has better results in the treatment of imn patients compared with cyclosporine. background immunosuppressive drugs have received the most attentio...

Cervical heterotopic heart transplants were performed on 20 male New Zealand white rabbits comprising 4 treatment groups. Animals in each group were injected daily via the marginal ear vein and received one of the following regimes: Cyclosporine A, 10 mg/kg/day; Cyclosporine G, 15 mg/kg/day; cremophor-El, 3ml/day; or normal saline. Measurement of 24 hour trough blood concentrations revealed no ...

We describe a 58-year-old female renal transplantant recipient with standard cyclosporine-based immunosuppression who developed a potentially toxic cyclosporine concentration of 265 ng/ml after having started acetazolamide for severe glaucoma. The mechanism explaining the interaction between acetazolamide and cyclosporine remains unknown, but the concomitant use of these agents is not uncommon....

Blood concentrations of cyclosporine were determined in adult and pediatric patients following orthotopic liver transplantation to quantitate cyclosporine blood clearance and oral absorption. Seventeen bioavailability studies were performed following transplantation surgery in nine children and seven adults. The intravenous cyclosporine study was performed following an average dose of 2.1 mg/kg...

INTRODUCTION Cyclosporine is the backbone of immunosuppression in kidney transplantation. However, it is associated with side effects, some of which are dose-dependent. We evaluated association between cyclosporine trough level and its side effects. MATERIALS AND METHODS In 50 kidney transplant recipients, serum cyclosporine level, fasting blood glucose, and serum creatinine were measured 7 t...

objective(s): repaglinide (rg) is an antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus. it has a good safety and efficacy profile in diabetic patients with complications in renal impairment and is an appropriate treatment choice, even for individuals with more severe degrees of renal malfunctions. the aim of the present study was to examine the protective...

Restenosis after balloon dilatation of stenosed coronary arteries is a major clinical problem. Because T lymphocytes occur in neointima and because cyclosporine inhibits T-lymphocyte proliferation, we tested the hypothesis that cyclosporine would attenuate neointimal proliferation after balloon dilation injury. Rabbits with a balloon-injured aorta, randomized to cyclosporine in the human therap...