Malignant peripheral nerve sheath tumor (MPNST) is a rare nerve sheath tumor derived from Schwann cells or pleuripotent cells of neural crest. Neurogenic tumors make about 10-20% of all mediastinal tumors. Incidence of MPNST is 0.001% in general population and 0.16% in patients with neurofibromatosis I (NF I). We report a case of 60 year female presenting with progressive cough and breathlessne...

Primary heart muscle disease is a cause of significant morbidity and mortality in childhood. The current WHO classification of cardiomyopathy is based on a combination of clinical features, aetiology and pathology. It is in need of revision because of accumulating genetic information concerning the pathogenesis of cardiomyopathy. It is becoming increasingly obvious that most of the primary hear...

Cell-cell communication and interaction is critical during fertilization and triggers free cytosolic calcium ([Ca2+]cyto) as a key signal for egg activation and a polyspermy block in animal oocytes. Fertilization in flowering plants is more complex, involving interaction of a pollen tube with egg adjoining synergid cells, culminating in release of two sperm cells and their fusion with the egg a...

argas reflexus is considered obligate blood feeder that may cause skin redness and local swelling. for histopathological evaluation of biting site, pigeons were used as natural host species in this study. adult ticks were collected from urmia, north-west of iran and kept in a desiccator before their use in the experiment. sixteen pigeons were infested experimentally and were divided into 4 grou...

Background: Fine Needle Aspiration Cytology (FNAC) is important for pre-operative and pre-treatment diagnosis of benign and malignant thyroid lesions, thus decreasing the incidence of unwanted surgeries. Objectives: The present study aims to classify various cytomorphological lesions of the thyroid according to The Bethesda System for Reporting of Thyroid Cytopathology (TBSRTC) and correlate th...

P-selectin glycoprotein ligand-1 (PSGL-1) serves as the leukocyte ligand for P-selectin, and many of the structural features of its ectodomain required for interactions with P-selectin have been uncovered. In contrast, the function of the highly conserved PSGL-1 cytoplasmic domain has not been explored. Stable transfectants expressing similar levels of either wild-type PSGL-1 or truncated PSGL-...

P-selectin glycoprotein ligand–1 (PSGL-1) serves as the leukocyte ligand for Pselectin, and many of the structural features of its ectodomain required for interactions with P-selectin have been uncovered. In contrast, the function of the highly conserved PSGL-1 cytoplasmic domain has not been explored. Stable transfectants expressing similar levels of either wild-type PSGL-1 or truncated PSGL-1...

We previously documented a ten-fold increase in gamma(cyto)-actin expression in dystrophin-deficient skeletal muscle and hypothesized that increased gamma(cyto)-actin expression may participate in an adaptive cytoskeletal remodeling response. To explore whether increased gamma(cyto)-actin fortifies the cortical cytoskeleton in dystrophic skeletal muscle, we generated double knockout mice lackin...