background: atherosclerosis, a chronic inflammatory disease of the vessel wall is characterized by local and systemic immune responses to a variety of antigens. oxidized low-density lipoprotein (oxldl) is considered as an important determining factor in the pathogenesis of atherosclerosis. objective: the purpose of this study was to investigate the degree of peripheral blood mononuclear cells (...

fragrant species of the genus salvia have been attributed many medicinal properties, which include anticancer activity. in the present study, cytotoxic properties of total methanol extract of salvia chloroleuca rech. f. & aellen and its fractions were investigated on mcf-7, a breast carcinoma cell line. malignant and non-malignant cells were cultured in rpmi medium and incubated with different ...

in the present study, aqueous solutions of some copper-complexing ligands were screened for their cytotoxicity using brine shrimp lethality test. among the ligands tested, diacetyl-bis(n4-methylthiosemicarbazones) (atsm) proved to be the most safe and non-toxic compound (2% lethality at 10 ppm), while pyruvaldehyde bis(n4-methyl)thiosemicarbazone (ptsm) was shown to possess low toxicity (7% let...

introduction: one of the major contributing factors, which may cause failure of endodontic treatment, is the presence of residual microorganisms in the root canal system. for years, most dentists have been using calcium hydroxide (ch) as the intracanal medicament between treatment sessions to eliminate remnant microorganisms. reducing the size of ch particles into nanoparticles enhances the pen...

nanotechnology is a rapidly growing field having potential applications in many areas. nanoparticles (nps) have been studied for cell toxicity, immunotoxicity, and genotoxicity. tetrazolium-based assays such as mtt, mts, and wst-1 are used to determine cell viability. cell inflammatory response induced by nps is checked by measuring inflammatory biomarkers, such as il-8, il-6, and tumor necrosi...

abstract background and aims: the number of new cancer cases with considerable mortality is increasing worldwide. since the inability of current therapies in treatment of patients and prevention the progress of tumors with fewer side effects, implementation of new methods is needed. gene therapy has widespread systemic cytotoxic effects against tumor cells. rotavirus nsp4 has been shown to elic...

background :wide distribution and low half-life of acyclovir has led to a high dose consumption of the drug. recent studies have shown that encapsulation of acyclovir in nano-carriers can increase effectiveness and decrease its side effects. we investigated the inhibitory effect of acyclovir loaded nano-niosomes against herpes simplex virus type-1 (hsv-1) in cell culture.   methods : in-vitro c...

background and objectives: the aerial part extracts of eremostachys macrophylla  from labiatae family, which has been traditionally used in wound healing, snake bites, rheumatism and joint pains, were investigated for general toxicity, anti-proliferative, free radical scavenging and anti-bacterial effects.moreover, preliminary phytochemical investigations were carried out on the extracts. metho...

pyrazine derivatives are important class of compounds with diverse biological and cytotoxic activities and clinical applications. in this study, b3 p 86 / 6 – 31 + + g * was used to compute and map the molecular surface electrostatic potentials of a group of substituted amides of pyrazine-2-carboxylic acids to identify common features related to their subsequent cytotoxicities. several statisti...

rheum turkestanicum janischew. (polygonaceae) is a plant that grows in central asia and in north-east of iran. traditionally, people use roots of r. turkestanicum as an anti-diabetic and anti-hypertensive as well as anticancer agent. in this study the cytotoxicity and apoptogenic properties of ethyl acetate (etoac), n-hexane and h2o extracts from rheum turkestanicum janischew. (polygonaceae) ro...