introduction: nanoparticles are being increasingly applied in dentistry due to their antimicrobial and mechanical properties. this in vitro study aimed to assess and compare the cytotoxicity of four metal oxide nanoparticles (tio 2 , sio 2 , zno, and al 2 o 3 ) on human dental pulp stem cells. methods and materials: four suspension with different concentrations (25, 50, 75, 100 µg/ml) of each n...

Objective(s): In this study a series of novel colchicine-like β-acetamidoketones was designed and synthesized as potential tubulin inhibitorsMaterials and Methods: The cytotoxicity of the novel synthesized β-acetamidoketones was assessed against two cancerous cell lines including MCF-7 (human breast cancer cells) and A549 (adenocarcinomi...

OBJECTIVES An in vitro screening test was used to compare the cytotoxicity and elemental release from mercury- and gallium-based dental restorative materials. METHODS The test employed three sequential extractions of the samples into cell-culture medium which were then used to evaluate the cytotoxicity of the samples and the release of elements from the samples. Cytotoxicity was measured by p...

In this paper, a polylactic acid (PLA)/polybutylene carbonate (PBC)/chitosan (CS) composite membrane with different mass fractions of ciprofloxacin hydrochloride (CipHCl) drug was prepared through the electrostatic spinning technology. The morphology and chemical structure resultant CipHCl-PLA/PBC/CS fiber membranes were characterized scanning electron microscopy (SEM), Fourier transform infrar...

objective: immunotoxins (its) have been developed for the treatment of cancer, and comprise of antibodies linked to toxins. also vascular endothelial growth factor (vegf) plays a key role in tumor angiogenesis, and the blockade of vegf receptor-2 (vegfr2) inhibits angiogenesis and tumor growth. the aim of this study was to produce anti-vegfr2/rpe (pseudomonas exotoxin) 38 it to test its cytotox...

Background. Programs of preclinical safety studies the health care products depend on regulatory status investigated products. The classification such products, in particular suppositories for rectal and vaginal use, is a critical step developing tactics their biological evaluation. Adaptation evaluation methods medical devices based combination biologically active substances, as well results u...

The cytotoxicity of the biomaterials is a key issue that should be addressed prior to pre-clinical applications. This study was designed to evaluate and compare the cytotoxixity of two forms of bioactive glasses:nanopowder:andmicropowder. Human HGF1-PI53 gingival fibroblast cells were used to evaluate the cytotoxicity of 0.5, 1, 1.5, 2, 5, 10, 15 and 20 mg/mL concentrations of the two bioactive...