Aberrant regulation of transition metals and the resultant disregulation of neuronal reactive oxygen species (ROS) are considered significant in the etiology of Alzheimer's disease (AD). We determined the solution structure of the D2 domain of APL-1 (APL1-D2), the Caenorhabditis elegans ortholog of the amyloid precursor protein domain 2 (APP-D2). The copper binding affinities of APL1-D2 and APP...

Chimeric D1/D2 receptors were constructed to identify structural determinants of drug affinity and efficacy. We previously reported that chimeras that had D1 receptor transmembrane domain VII together with amino-terminal sequence from the D2 receptor were nonfunctional. D2/D1 chimeras were constructed that contained D2 receptor sequence at the amino- and carboxyl-terminal ends and D1 receptor s...

[1] A means of upscaling the effective saturated hydraulic conductivity, hKi, based on spatial variation in the saturated hydraulic conductivity (K) field is essential for the application of flow and transport models to practical problems. Multifractals are inherently scaling and thus may offer solutions to this dilemma. Random two-dimensional geometrical multifractal fields (multifractal Sierp...

A macroscopic approximation of RNA secondary structure (Vialette, CPM 2002): • a subsequence of consecutive bases → an interval • a stacked pairing of two disjoint subsequences → a 2interval Three Binary Relations For two 2-intervals D1 = (I1, J1) and D2 = (I2, J2), D1 and D2 are disjoint if the four intervals I1, J1, I2, and J2 are pairwise disjoint. Preceding: D1 < D2 ⇐⇒ I1 < J1 < I2 < J2. Ne...

previous studies had reported that extracellular levels of ascorbic acid have modulatory effects on dopamine receptors. both ascorbic acid and dopamine receptor have an important role in learning and memory processes. however, the central interaction between ascorbic acid and dopamine d2 receptor on spatial learning and memory has not yet been elucidated. all experiments were carried out on mal...

Linear complementary dual (LCD) codes are linear that intersect with their trivially. We study the largest minimum weight d2(n,k) among all binary LCD [n,k] and d3(n,k) ternary codes. The weights d2(n,5) d3(n,4) partially determined. also determine d2(n,n−5), d3(n,n−i) for i∈{2,3,4}, n∈{11,12,…,19}.

The (F1,D2,D8) brane configuration with $Lif_4^{(2)}\times {S}^1\times S^5$ geometry is a known Lifshitz vacua supported by massive $B_{\mu\nu}$ field in type IIA theory. This system allows exact IR excitations which couple to massless modes of the fundamental string. Due these solutions have flow dilatonic $Lif_4^{(3)}\times S^1\times IR. We study entanglement entropy on boundary this spacetim...

CONTEXT The iodothyronine deiodinases D1, D2, and D3 enable tissue-specific adaptation of thyroid hormone levels in response to various conditions, such as hypothyroidism or fasting. The possible expression of D2 mRNA in skeletal muscle is intriguing because this enzyme could play a role in systemic as well as local T3 production. OBJECTIVE We determined D2 activity and D2 mRNA expression in ...

The Godhra-Chhota Udepur (GC) sector (west-central India) is the zone of convergence between two crustal-scale accretion zones, i.e. N/NNE-striking Aravalli Delhi Fold Belt (ADFB) against E-striking Central Indian Tectonic Zone (CITZ). In this study, we demonstrate orogens welded during Early Neoproterozoic. GC sector, recumbently folded basement gneisses, shallow-dipping granitoid mylonites an...