MfpA(Mt) and QnrB4 are two newly characterized pentapeptide repeat proteins (PRPs) that interact with DNA gyrase. The mfpA(Mt) gene is chromosome borne in Mycobacterium tuberculosis, while qnrB4 is plasmid borne in enterobacteria. We expressed and purified the two PRPs and compared their effects on DNA gyrase, taking into account host specificity, i.e., the effect of MfpA(Mt) on M. tuberculosis...

BACKGROUND AND OBJECTIVE Hb Lepore is a structurally abnormal hemoglobin in which the abnormal globin chain is a hybrid or fused globin chain (db). Three different Lepore hemoglobins have been identified, differing from each other in the point at which the db fusion occurs; Hb Lepore Hollandia (d22/b50), Hb Lepore Baltimore (d59/b86) and Hb Lepore Boston (d87/b116). In Spain only Hb Lepore Bost...

Upon viral infection, cells commit suicide and die by Successful implosion of a building depends on the preapoptosis as an altruistic defense mechanism to benefit cise and timely detonation of explosives. If a cell underthe organism. Several viruses have built into their gegoing apoptosis is analogous to an imploding building, nome apoptosis-inhibiting arsenal, including proteins then the explo...

BACKGROUND & OBJECTIVES Infection with Salmonella enterica serovar Typhi (hereafter S. Typhi) is an important public health problem in India. There has been an increase in the number of reported clinical failures to ciprofloxacin treatment but the data on possible mechanism of failure are limited. One mechanism that has been widely reported and found associated with ciprofloxacin resistance, is...

Background: The pathophysiology of upper gastrointestinal (GI) symptoms is still poorly understood. Psychological symptoms were found to be more common in patients with functional gastrointestinal complaints, but it is debated whether they are primarily linked to GI symptoms or rather represent motivations for healthcare seeking. Purpose of our study was to compare co-morbidity, in particular p...

CD24 is overexpressed in many human cancers and a driver of tumor progression. Herein, molecular mechanisms leading to up-regulation prostate cancer were studied. DNA methylation the gene promoter at four loci using quantitative methylation-specific PCR was evaluated. Expression tissues studied by immunohistochemistry. To corroborate results vitro, ERG-inducible LNCaP TMPRSS2:ERG (T2E) cells lu...

We have investigated the near liquidus phase relations of a primitive absarokite from the Mascota region in Western Mexico. Sample M. 102 was chosen because it has high MgO contents, a high Mg# and Fo90 olivine phenocrysts, indicating it is primitive mantle melt. Highpressure experiments on a synthetic analogue of the absarokite composition with a H20 content of either -1.7 wt% or -5.1 wt% were...