BACKGROUND Dementia in Parkinson's disease (PD) is defined as cognitive decline severe enough to affect activities of daily living function (ADL). The aim of our exploratory study was to compare two groups of PD patients. Both groups had cognitive deficits severe enough to justify diagnosis of dementia, but they differed according to caregivers' rating on ADL dysfunction. Parameters which diffe...

background: one of the problems that addicts suffer from is decreased libido. erectile dysfunction has been reported in men using opioids for treatment of heroin addiction. objective: the study was performed to investigate the effects of morphine and detoxification with methadone as causes of sexual dysfunction in addiction. methods and methods: a total of 40 adult male rats (wistar) were used....

Risk of hospital readmission and cardiac mortality increases with atmospheric pollution for patients with heart failure. The underlying mechanisms are unclear. Carbon monoxide (CO) a ubiquitous environmental pollutant could be involved. We explored the effect of daily exposure of CO relevant to urban pollution on post-myocardial infarcted animals. Rats with ischemic heart failure were exposed 4...

BACKGROUND Cognitive dysfunction has been observed in a range of liver diseases including chronic hepatitis C virus, alcoholic liver disease, primary biliary cirrhosis and Wilson's disease. Such dysfunction may range from mild cognitive changes to overt hepatic encephalopathy, and represents a significant complication of liver disease that may negatively impact the patient's quality of life, an...

There has been considerable interest in the neurocognitive functioning of subjects with mood disorders (Bcardcn ct al., 2001). I "'torn a theoretical viewpoint, the dysfunction provides insight (especially when monitored with fMlll) into the biological underpinnings, for example, structure and pathway integrity, of mood disorders. From a practical viewpoint, neurocognitive dysfunction underpins...

OBJECTIVE To highlight diagnostic and therapeutic issues about Rathke cleft cysts for otorhinolaryngologists. STUDY DESIGN Retrospective. METHODS We retrospectively reviewed data collected on Rathke cleft cysts between 1978 and 1998: presenting symptoms, visual acuity, surgical treatment, complications, recurrences, and effect on daily activity. RESULTS Twenty-nine patients were diagnosed...

In Alzheimer's-type dementia, significant nerve cell degeneration is seen in the medial temporal lobe, including the hippocampal region, and in the temporoparietal association area. As symptoms progress, impairments in various behaviours begin to occur in daily life. In particular, higher brain dysfunction, including parietal association area dysfunction, are major impediments to providing care...

A 17-year-old woman was previously diagnosed with autoimmune hepatitis (AIH) by liver biopsy. Adult-onset Still's disease (AOSD) was subsequently diagnosed on the basis of high fever, arthralgia, erythema, leukocytosis (>80% granulocytes), cervical lymph node swelling, splenomegaly, and hyperferritinemia. Her symptoms and liver dysfunction improved with prednisolone of 60 mg daily and subsequen...

OBJECTIVE To determine whether a rapid qualitative assay for the detection of circulating endotoxin (SimpliRED Endotoxin Test [SRE]; AGEN, Inc; Brisbane, Australia) can predict the occurrence of multiorgan dysfunction and hospital mortality. To compare the SRE to the limulus amebocyte lysate (LAL) assay as a predictor of clinical outcomes. DESIGN Prospective, blinded, single-center study. S...

Outcomes: Primary outcomes: cognitive dysfunction (Severe Impairment Battery (SIB)); activities of daily living (modified 19 item Alzheimer’s disease Co-operative Study-Activities of Daily Living Inventory (ADCS-ADL19)). Secondary outcomes: effects of medication (Clinician’s Interview-Based Impression of Change Plus Caregiver Input (CIBIC-Plus)); frequency and severity of behavioural symptoms (...