Hyoscyamine, anisodamine and scopolamine are tropane alkaloids present in some Solanaceae species used modern medicine. L-Hyoscyamine is hydroxylated to 6β-hydroxyhyoscyamine (anisodamine) then epoxidated by the dual action of hyoscyamine 6β-hydroxylase (H6H), a 2-oxoglutarate dependent dioxygenase. A natural mutation Gly-220 residue Cys was previously shown be associated with loss function H6H...

background: the use of natural products as anticancer and antioxidant agents has a long history. several drugs currently used in chemotherapy were isolated from plant species. objective: the aim of this study was to evaluate cytotoxicity and antioxidant activity as well as phenol and flavonoid contents of five plant species of solanaceae family. methods: five plant species of solanaceae family ...