BACKGROUND DCB-3503, a tylophorine analog, inhibits the growth of PANC-1 (human pancreatic ductal cancer cell line) and HepG2 (human hepatocellular cancer cell line) tumor xenografts in nude mice. The inhibition of growth leads to cancer cell differentiation instead of cell death. However, the mechanisms of action of tylophorine analogs is unknown. METHODOLOGY/PRINCIPAL FINDINGS In this study...

Three main collaborative beamforming (CB) solutions based on different channel models exist: the optimal CSI-based CB (OCB), the conventional or monochromatic (i.e., single-ray) distributed CB (M-DCB), and the recently developed bichromatic (i.e., two-ray) distributed CB (B-DCB). In this paper, we perform an analytical comparison, under practical constraints, between these CB solutions in terms...

OBJECTIVES The authors sought to understand the clinical and angiographic outcomes of dissections left after drug-coated balloon (DCB) angioplasty. BACKGROUND Second-generation DCB may be an alternative to stents in selected populations for the treatment of native coronary lesions. However, the use of these devices may be hampered by a certain risk of acute vessel recoil or residual coronary ...

The paclitaxel drug-coated balloon (DCB) is an emerging device in percutaneous coronary intervention, which has shown promising results by means of a high-concentration, rapid local release of an antirestenotic drug without the use of a durable polymer or metal scaffold. DCB have already proven effective in clinical trials for the treatment of in-stent restenosis. Its coronary applications may ...

PURPOSE To assess the safety and effectiveness of the MDT-2113 (IN.PACT Admiral) drug-coated balloon (DCB) for the treatment of de novo and native artery restenotic lesions in the superficial femoral and proximal popliteal arteries vs percutaneous transluminal angioplasty (PTA) with an uncoated balloon in a Japanese cohort. METHODS MDT-2113 SFA Japan ( ClinicalTrials.gov identifier NCT0194747...

BACKGROUND In severe injuries with loss of tendon substance a tendon graft or a synthetic substitute is usually used to restore functional length. This is usually associated with donor site morbidity, host tissue reactions and lack of remodelling of the synthetic substitutes, which may result in suboptimal outcome. A biocompatible graft with mechanical and structural properties that replicate t...

Cellulose is an important component of cell wall, yet its location and function in pollen tubes remain speculative. In this paper, we studied the role of cellulose synthesis in pollen tube elongation in Pinus bungeana Zucc. by using the specific inhibitor, 2, 6-dichlorobenzonitrile (DCB). In the presence of DCB, the growth rate and morphology of pollen tubes were distinctly changed. The organiz...

In this work, the mode I fracture toughness of dissimilar metal-composite adhesive joints is experimentally investigated using double cantilever beam (DCB) test. The particular joint under study resulted by joining a thin titanium sheet with carbon fiber reinforced plastic (CFRP) laminate and envisioned to be implemented in hybrid laminar flow control system future aircraft. Four different indu...

2015 Despite initially encouraging technical success after femoropopliteal percutaneous transluminal angioplasty (PTA), postprocedural restenosis remains the major challenge. Antiproliferative drugs applied via drug-coated balloons (DCBs) or drug-eluting stents suppress neointimal hyperplasia, the main cause of restenosis. The present article summarizes results of DCB treatments of femoropoplit...