OlympiA is the first phase III randomised clinical trial (RCT) testing a PARP inhibitor as adjuvant therapy. At event driven interim analysis [Data CutOff 1 (DCO1), 27/03/20; median follow up (MFU) 2.5 years] OL significantly improved primary endpoint of invasive disease-free survival (IDFS) and secondary distant DFS (DDFS) compared with placebo (PL) [both p<0.001]. OS did not cross pre-specifi...

A low–complexity direct digital frequency synthesizer based on linear interpolation method is presented in this paper. The proposed architecture employs a new technique to derive the slope coefficients at the first sample of each segment's interval thereby eliminating the ROM which stores those values. ROM elimination has resulted in significant logic element saving and simplified the whole DDF...

Purpose: Loss of function of PTEN is a frequent event inmelanoma, particularly in tumorswithBRAF mutations. The prevalence, pathologic features, and clinical outcomes associated with PTEN loss in patients with stage IIIB/C melanoma were interrogated to improve our understanding of the clinical significance of this molecular event. ExperimentalDesign:Archival tissue from lymphadenectomy specimen...

Purpose: Loss of function of PTEN is a frequent event inmelanoma, particularly in tumorswithBRAF mutations. The prevalence, pathologic features, and clinical outcomes associated with PTEN loss in patients with stage IIIB/C melanoma were interrogated to improve our understanding of the clinical significance of this molecular event. ExperimentalDesign:Archival tissue from lymphadenectomy specimen...

PURPOSE Loss of function of PTEN is a frequent event in melanoma, particularly in tumors with BRAF(V600) mutations. The prevalence, pathologic features, and clinical outcomes associated with PTEN loss in patients with stage IIIB/C melanoma were interrogated to improve our understanding of the clinical significance of this molecular event. EXPERIMENTAL DESIGN Archival tissue from lymphadenecto...

BACKGROUND The correlation between body mass index (BMI) and patient and tumor characteristics related to prognosis has not been well explored and may help to elucidate the mechanisms involved in the carcinogenesis. Because of the equivocal, inconsistent and uncertain research results as well as racial and ethnic differences, we aimed to evaluate the prognostic significance of high BMI in Turki...

By Zhihe Zhou, Ph.D. Washington State University August 2006 Chair: George S. La Rue We investigated the design and implementation of non-linear D/A converters (DAC) for a direct digital frequency synthesizer (DDFS), which consists of a phase accumulator, a phase-to-sine look-up table and a DAC. Using a non-linear DAC can significantly reduce the look-up table size, hence, reducing the power di...

With the utilization of the multirate sampling, both the channel selection and frequency uptranslation with simultaneous sampling rate increase is achieved by the proposed SwitchedCapacitor (SC) bandpass interpolating filter for an efficient Direct-Digital Frequency Synthesis (DDFS) system with the resulting dual rewards in the speed reduction to DDFS digital core plus Digital-to-Analog (DAC) a...

BACKGROUND To determine the impact of micrometastatic bone marrow cells (MMC) on survival in high-risk primary breast cancer (HRPBC) patients treated with high-dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT). PATIENTS AND METHODS Ninety-one HRPBC patients (73 patients with > or =10 involved axillary lymph nodes (ALN), 18 premenopausal women with > or =4 involved ALN) ...