Purpose: Osteoarthritis is a prevalent degenerative joint disease with huge public health burden and no curative therapy. There clear urgent need to translate insights from genomics into better understanding of mechanisms. A hallmark osteoarthritis cartilage degradation. Here, we aim characterize molecular events in at the whole transcriptome level.

Functions of the ankle joint are closely connected with the gait and ability to maintain an upright position. Degenerative lesions of the joint directly contribute to postural disorders and greatly restrict propulsion of the foot, thus leading to abnormal gait. Development of total ankle replacement is connected with the use of the method as an efficient treatment of joint injuries and continua...

In March 2006, the Joint Section on Disorders of the Spine and Peripheral Nerves of the American Association of Neurological Surgeons and Congress of Neurological Surgeons compiled an expert group to perform an evidence-based review of the clinical literature on management of cervical degenerative spine disease. This process culminated in the formation of the Guidelines for the Surgical Managem...

INTRODUCTION Degenerative joint disease and associated pain are common in cats, particularly in older cats. There is a need for treatment options, however evaluation of putative therapies is limited by a lack of suitable, validated outcome measures that can be used in the target population of client owned cats. The objectives of this study were to evaluate low-dose daily meloxicam for the treat...

According to Langen (1934), who made an extensive study of the pathology of degenerative processes in the sterno-clavicular joint in 200 necropsies, it may be involved from the age of 20 and constantly shows signs of osteo-arthritis after the age of 50. However, few authors seem to have made clinical observations of degenerative disease at this site (Bonola and Mastragostino, 1954; Westermann, ...

A clinical and radiological study of upper and lower limb joints was carried out on 25 experienced weight-lifters to identify the extent of degenerative joint disease (Osteoarthrosis) produced by this sport. Although significant degenerative changes were found in five lifters (20%). This figure is not greater than that found in the general population within the age group studied. There were mor...

Arthrosis is synonymous to osteoarthritis (OA) which is common degenerative disease of a joint in elderly and coxarthrosis specifically refer to hip joint osteoarthritis and it can be primary or secondary of which the latter due to other inflammatory joint disorders. Both arthrosis and arthritis shared some common clinical features such as pain and tenderness, stiffness and limited range of joi...

An adequate level of physical activity has a substantial effect on both mental and physical human health. Physical activity is largely dependent on the function of the musculoskeletal and articular system. One of the most frequent diseases of this system is degenerative joint disease. Due to the changing and more demanding lifestyles and patients' willingness to be involved in sports activity, ...