نتایج جستجو برای: dehydro aromatization
تعداد نتایج: 1931 فیلتر نتایج به سال:
Aromatization of androgens in the central nervous system is linked with sexual differentiation of the brain and, thus, determines the nature of sexual behavior and the control of gonadotropin secretion. The process of aromatization, as determined in the human placenta, proceeds through two successive hydroxylations at C-19, the products of which are then virtually completely converted via a thi...
BACKGROUND AND PURPOSE Enhanced thromboxane (TX) biosynthesis has previously been reported in the acute phase after ischemic stroke. We investigated whether enhanced urinary excretion of 11-dehydro-TXB2, a noninvasive index of platelet activation, was present in the chronic phase after a transient ischemic attack (TIA) or stroke, including intracerebral hemorrhage. METHODS We obtained a singl...
BACKGROUND Increased formation of 8-iso-prostaglandin (PG) F(2alpha) and thromboxane (TX) A(2), potent agonists of platelet and vascular thromboxane (TH)/PGH(2) receptors, has been detected in cigarette smokers. We performed a randomized, double-blind, placebo-controlled study of the effects of vitamin E (300, 600, and 1200 mg/d, each dose for 3 consecutive weeks) on 8-iso-PGF(2alpha) and TXA(2...
The conversion of androgenic steroids to the phenolic estrogens by mammalian tissue has been well documented. The reaction has been reported in relatively low yield, in vitro with ovarian and placental slices (l-3), and in viva after the administration of androgens to various species including man (4, 5). The present report describes the conversion of androgens to estrogens in high yield by a s...
Background and aims As our understanding of platelet activation in response to infections and/or inflammatory conditions is growing, it becoming clearer that safe, yet efficacious, platelet-targeted phytochemicals could improve public health beyond the field cardiovascular diseases. The phytonutrient sulforaphane shows promise for clinical use due its effect on pathways, favorable pharmacokinet...
Thirty-four alkaloids were identified in the organs of Hyoscyamus albus L. by gas-liquid chromatography-mass spectrometry (GLC-MS). Eight new compounds for the roots, eleven for the stems, twelve for the leaves, nineteen for the flowers, and seven for the seeds were detected. The alkaloids 5-(2-oxopropyl)-hygrine (8) and phygrine (20) are new for this species and 3-(hydroxyacetoxy)tropane (9), ...
At Case Western Reserve University in Cleveland, the known intermediate steps in the aromatization, catalyxed by human placental microsomes, of 4-androstene-3, 17-dione to estrone were evaluated. Oxygen and carbon monoxide atmospheres were used to expose the properties of the participating oxidases. The results were judged to be evidence for the existence of 3 mixed function oxidases active i...
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