The aim of the present study was to investigate the role of bradykinin in the inhibitory action of captopril in hypertension induced by L-NAME in anesthetized rats. Male Wistar rats (260-320 g) were anesthetized with chloralose and arterial blood pressure was recorded with a polygraph pressure transducer. The hypertensive effect of L-NAME was studied in rats pretreated with saline, captopril or...

Activation by opioid receptors of cell proliferation was examined with fibroblast cell lines stably expressing either delta-opioid or mu-opioid receptors. Addition of [D-Ala2, D-Leu5]-enkephalin or [D-Pen2,D-Pen5]-enkephalin to Chinese hamster ovary (CHO) cells transfected with delta-opioid receptor cDNA resulted in an agonist concentration-dependent potentiation of fetal calf serum (FCS)-stimu...

Notch is a major factor mediating interaction between hematopoietic progenitor cells (HPCs) and bone marrow stroma (BMS). However its contribution to dendritic cell (DC) differentiation is controversial. We found that main Notch ligands Delta-1 and Jagged-1 had the opposite effect on DC differentiation. Delta-1 promoted generation of fully differentiated DCs, whereas Jagged-1 stimulated accumul...

let $mathfrak{a}$ be an algebra. a linear mapping $delta:mathfrak{a}tomathfrak{a}$ is called a textit{derivation} if $delta(ab)=delta(a)b+adelta(b)$ for each $a,binmathfrak{a}$. given two derivations $delta$ and $delta'$ on a $c^*$-algebra $mathfrak a$, we prove that there exists a derivation $delta$ on $mathfrak a$ such that $deltadelta'=delta^2$ if and only if either $delta'=0$...

Cholecystokinin octapeptide (CCK-8) is reported to antagonize the analgesic effect produced by mu- and kappa- but not delta-opioid agonist in spinal cord. However, the mechanisms of interaction remain obscure. In the present study, whole-cell patch-clamp recording was performed on acutely isolated rat dorsal root ganglion (DRG) neurons to evaluate the effects of the highly specific mu-opioid ag...

poverty is the most serious threat to natural resources and the environment and most of the poor are rural-based who engage in various agricultural activities. land is a critical asset for the rural poor and lacking means to appropriately intensify agriculture which compels the poor to either overuse or misuse this natural resource base to meet basic needs. this study presents empirical relatio...

as special depositional environments which are adjacent to the seas, deltas have provided a field for human habitat establishment. geomorphic features of deltas are in constant transformation due to their dynamic features. constructing dams on rivers can intensify these changes and cause either negative or positive consequences. minab delta in hormozgan province of iran is a round or crescent-s...

The homothallic, filamentous ascomycete Sordaria macrospora is self-fertile and produces sexual fruiting bodies (perithecia) without a mating partner. Even so, S. macrospora transcriptionally expresses two pheromone-precursor genes (ppg1 and ppg2) and two pheromone-receptor genes (pre1 and pre2). The proteins encoded by these genes are similar to alpha-factor-like and a-factor-like pheromones a...

It is shown that dinoseb, added to subchloroplast photosystem-II (PS-II) preparations from pea at a concentration higher than 5 microM, along with blocking the electron transfer on the acceptor side of PS-II, induces the following effects revealing its capability to have redox interaction with the components of PS-II reaction center (RC)-pheophytin (Pheo) and chlorophyll P680: (1) acceleration ...