Background: Harlequin ichthyosis (HI) is a severe and rare autosomal recessive congenital ichthyosis, characterized by hyperkeratosis, extensive fissuring massive, diamond-shaped scales which limit the child’s movements. The term harlequin comes from baby’s facial expression pattern of like 17th century entertainers, harlequins. underlying genetic abnormality has been identified as mutation in ...

The most successful exorcism of Maxwell’s demon is Smoluchowski’s 1912 observation that thermal fluctuations would likely disrupt the operation of any molecular-scale demonic machine. A later tradition sought to exorcise Maxwell’s demon by assessing the entropic cost of the demon’s processing of information. This later tradition fails since these same thermal fluctuations invalidate the molecul...

'There's nothing like a spot of demon slaughter to make a girl's night' Since the phenomenal success of the Tomb Raider (1996) videogame series a range of other videogames have used carefully branded animated female avatars. As with most other media, the game industry tends to follow and expand on established lucrative formats to secure an established market share. Given the capacity of videoga...