Objective(s): Protosappanin A (PrA) is an effective and major ingredient of Caesalpinia sappan L. The current study was aimed to explore the effect of PrA on atherosclerosis (AS). Materials and Methods: Firstly, the experimental model of AS was established in rabbits by two-month feeding of high fat diet. Then, the rabbits were randomly divided into five groups and treated with continuous high ...

Background and Aims: Atherosclerosis is currently a chronic disease in which cholesterols accumulate in large arteries. Many genes such as liver X receptor α (LXRα) are involved in the cholesterol homeostasis. Curcumin, the main active polyphenol component derived from Curcuma longa, contribute to anti-inflammation and antioxidant in the treatment of atherosclerosis. Thus, this stud...

Metabolic syndrome (MetS) is a major metabolic disorder worldwide which is characterized by having three or more of the five metabolic abnormalities. These metabolic abnormalities include abdominal obesity (waist circumference &ge; 90 cm for men and &ge; 80 cm for women), high triglyceride levels (TG) (&le; 150 mg/dL), decreased high density lipoprotein cholesterol (HDL-c) (< 40 mg/dL in men an...

the antimicrobial effectiveness of different extracts of chicory (cichorium intybus l.) plant including methanolic, ethylic acetate, chloroformic, and aqueous extracts was evaluated by disk diffusion method. the ethylic acetate extract showed higher antibacterial activity against e. coli compared with others. then, effects of different levels of ethylic acetate extract on growth performance and...

The plasma appearance of newly synthesized cholesterol in anhepatic laboratory diet-fed rats was 10% of the intact rat. In intact rats this cholesterol was mainly ester in lower density lipoproteins, but for anhepatic rats it was virtually only free in high density lipoprotein. Chylomicron cholesterol ester was removed much more slowly from anhepatic than control plasma and returned primarily a...

Because the ingestion of some types of dietary fibers has been shown to influence on the lipid and lipoprotein levels, it is possible that chitosan influences on lipid metabolism. In the present study, the effects of chitosan on the serum, liver lipid and lipoprotein concentrations in rat were investigated. Serum lipid level in the treatment groups were decreased compared to that of the control...

results saffron extracts markedly (p < 0.05) decreased the serum total cholesterol (tc, 90 ± 9.3), triglyceride (tg, 99 ± 10.5), and low-density lipoprotein cholesterol (ldl-c, 27 ± 1.1) in obese rats, while they increased the serum high-density lipoprotein cholesterol (hdl-c, 68 ± 2.2). the atherosclerosis-index (ldl/hdl, 0.39 ± 0.5), atherogenic index (tc/hdl, 1.32 ± 4.2), and the liver enzym...