Background: Previous studies have shown the beneficial effects of Prosopis species in the treatment of diabetes in traditional medicine. This study was performed to evaluate the antihyperglycemic effects of Prosopis farcta (P.farcta) in streptozocin- induced diabetic rats. Methods: Diabetes was induced by intraperitoneal injection of streptozocin (55mg/kg...

This study was intended to assess the effect of Gymnema sylvestre leaf extract on AMPK-GLUT4 mediated signalling pathway insulin resistance in polycystic ovarian syndrome-induced rats. For induction PCOS rats, 1 mg/kg letrozole given orally for 21 days, after that metformin (300 mg/kg), (200 mg/kg, and 400 p. o.) were administered further 28 days. Letrozole-induced rats illustrated significant ...

introduction: several studies have reported the involvement of age-related changes in the development of neuropathic pain behaviors. however, limited data are available on the role of age in establishing and maintaining chronic neuropathic pain after peripheral nerve injury. methods: in the present study, we examined age-related neuropathic behavior among rats in 4 age groups: pups (4 weeks old...

background: melatonin is a free radical scavenger. it has also antioxidant effects through its stimulatory actions on antioxidant system. objective: we conducted this study to examine the effect of different oral doses of melatonin on liver tissue. methods: we used 42 rats—6 rats in each group. group i served as the control group; group ii rats were pretreated with only melatonin; group iii was...

background: chronic administration of morphine cause physical dependence but the exact mechanism of this phenomenon remains unclear. the aim of this study is the assessment of systemic and intracerebroventricular (icv) administration of ramelteon (a melatonin receptor agonist) on morphine physical dependence. methods: 88 adult male rats were divided into 2 major groups, namely “systematic” and ...

Background: Experiments have shown that opioid drugs abuse during pregnancy can cause a delay in the development of the placenta. In mammals, the placenta is the most important channel for the exchange of Materialss between the maternal and fetal bloods. The present study investigates the time-dependent effect of the addiction duration of maternal morphine consumption during pregnancy. Material...

An irreversible inhibitor of complex II in the mitochondria, 3-nitropropionic acid (3-NP), induces bilateral striatal lesions with many neuropathological features of Huntington’s disease (HD) in rats. It is widely used as a model of HD. Chronic systemic treatment of 3-NP for 4 days in rats (10, 15 and 20 mg/kg) caused a significant dose-dependent reduction in succinate dehydrogenase activity, w...

The increasing use of plant-based medicines necessitates safety evaluations all medicinal plants. This study evaluated the effects mango (Mangifera indica) leaf extracts on albino rats (Rattus norvegicus). phytochemistry plant’s extract was evaluated, followed by a determination its acute toxicity using 24 rats. Thereafter, chronic determined another set rats, separated into four groups six eac...

this study investigates the effectiveness of the antinociceptive effects of diclofenac, an nsaid, on the nociceptive behavior of morphine-treated rats on formalin test.rats were treated with morphine-containing drinking water for twenty one days, which induced morphine dependence. the antinociceptive effects of 8, 16, and 32 mg/kg doses of diclofenac were then evaluated and compared with distil...