normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background : vitiligo is an acquired, autoimmune melanocytic disorder characterized by circumscribed depigmented macules and patches. it affects approximately 0.5-2% of the general population worldwide. many medical treatments have been attempted with partial success, but there has been no previous trial on the combination...

Background: Vitiligo is a common skin disease that clinically presents as depigmented macules due to destruction of melanocytes. Although the cause is unknown, various theories such as autoimmune, autodestruct and neural hypotheses have been proposed. Objective: The objective of this study was to evaluate clinical picture of vitiligo in Isfahan, Iran. Patients and Methods: In a descriptive stud...

Advancements in novel combination immunotherapies as well innovative downstream management courses offer great optimism for the applicability of emerging cancer immunotherapy to prospective treatment cold tumours. This review comprehensively analyses and discusses notable current research directions field underscores future continued scientific progress alongside relevant clinical applications....

Halo (Sutton's) phenomenon has been described as a depigmented halo that is associated most commonly with acquired melanocytic nevi; but it may be associated with various types of melanocytic skin tumors, melanoma being the most concerning. Different authors have been preoccupied with elucidating morphological features of melanocytic tumors associated with a depigmented halo. We reviewed the li...

To clarify the mechanism of accentuated melanisation in non-syndromic solitary cafe-au-lait macules we used an enzymelinked immunosorbent assay (ELISA) to measure the concentration of melanogenic cytokines secreted by cultured keratinocytes and fibroblasts derived from the skins of the macules and compared them with those derived from normal people. Endothelin-1 (ET-1) was significantly increas...

Background: Vitiligo is a skin disorder characterized by selective loss of melanocytes resulting in circumscribed, depigmented macules and patches. Although it does not cause physical pain that warrants patient to complain, its effects can be psychological, leading stigmatization suicidal ideation.
 Patients methods: We conducted cross-sectional study with descriptive aim over period one y...

BACKGROUND Fundus autofluorescence studies in eyes with macular holes (MHs) have shown a hyperautofluorescent spot corresponding to the hole and a hypoautofluorescent ring corresponding to the fluid cuff surrounding the hole. The purpose of this report is to present three cases of MH with a different fundus autofluorescence pattern. CASE REPORTS Case 1 was a 62-year-old woman who did not know...

CASE 1 A 25-year-old man first noticed depigmented lesions on the face and neck; a few days later he developed asymptomatic erythematous papular and scaly lesions over the trunk and extremities, and moist papular lesions on the scrotal skin. Two weeks later when he reported to us, some of the trunk lesions had also become depigmented. Four months earlier after an extramarital sexual exposure, t...