Progesterone exerts beneficial effects on the human cardiovascular system by inducing rapid increases in nitric oxide (NO) production in vascular endothelial cells, but the receptors mediating these nongenomic progesterone actions remain unclear. Using human umbilical vein endothelial cells (HUVECs) as a model, we show that progesterone binds to plasma membranes of HUVECs with the characteristi...

This study aims to analyze the relationship between nutritional status, type and duration of contraceptive pills, 1-month injection Depo Medroxy Progesterone Acetate (DMPA) with menstrual disorders in women childbearing age Kupang City. The method used is a quantitative cross-sectional design. sampling technique was simple random stratified sampling. results showed that there status value (P = ...

This study was conducted to determine the effect of progestin source on some reproductive performance, lamb birth weight and mortality rate in Akkaraman ewes. A total 40 sheep breed with similar body (51.3 ± 1.5 kg) at least two parturitions were used as experimental animals. In all ewes, intramuscular injection PGF2α (2.5 mg) administered 96 hours before estrus synchronization obtain corpus lu...

Dairy cows that are being cared for in family businesses were used to compare the pregnancy rates by applying different time periods, using progesterone devices, and fixed-time artificial inseminations. The randomly divided into 3 groups. Group 1(n = 56); On day 0, GnRH (IM) (10mg Buserelin acetate, Ovarelin, CEVA DIF) + Progesterone implants (PRID®) (1,55 g CEVA), Day 8 PGF2α (Dinoprost tromet...

RATIONALE Endometrial cancer patients with lung metastases are rare, and more rarely with long-term management of progesterone after recurrence. PATIENT CONCERNS Informed consent of the patients and their families. DIAGNOSES Endometrial cancer (IVB) (Refer to 2009 FIGO stag of endometrial cancer). INTERVENTIONS the patient was treated with Megestrol Acetate Dispersible Tablets (trade name...

In vitro experiments were performed to investigate the effects of melengestrol acetate (MGA) or progesterone (P4) on bovine muscle satellite cells and C2C12 myoblasts. Addition of MGA at physiological and supraphysiological concentrations resulted in a dose-dependent decrease (P < 0.05) in DNA synthesis as measured by [3H]-thymidine incorporation (TI). Similarly, P4 addition (0.01 nM) reduced (...

Because progesterone exerts its effects mainly via estrogen-dependent progesterone receptor (PgR), the expression of progesterone's effects may be overshadowed by the priming effect of estrogen. PgR expression vectors were transfected into estrogen receptor (ER)-alpha and PgR-negative breast cancer cells MDA-MB-231; thus the functions of progesterone could be studied independent of estrogens an...

Fomin, Victor P., Blair E. Cox, and R. Ann Word. Effect of progesterone on intracellular Ca21 homeostasis in human myometrial smooth muscle cells. Am. J. Physiol. 276 (Cell Physiol. 45): C379–C385, 1999.—Although it is well known that progesterone alters uterine contractility and plays an important role in maintenance of pregnancy, the biochemical mechanisms by which progesterone alters uterine...