The properties of the depot fats of animals depend, to some extent, upon the nature of the dietary fats. Thus it was shown by Anderson and Mendel (1) that feeding of highly unsaturated oils results in the deposition of a body fat of high iodine number, whereas the administration of “hard” fat in the diet leads to a decrease in the iodine number of the depot fats. Recently Longenecker and Hildit...

A 50-year-old male patient with comorbid human immunodeficiency virus developed a relapse of bipolar disorder after a switch from oral aripiprazole 10 mg/day to intramuscular aripiprazole depot 200 mg every 28 days plus oral aripiprazole 5 mg/day. The patient was concomitantly taking lopinavir, saquinavir, ritonavir, silybum marianum extract, and omeprazole. Only 1 week after the switch, the pa...

ID: I935 Timothy W. Duket and Seokcheon Lee School of Industrial Engineering, Purdue University West Lafayette, IN 47906

This article addresses an extension of the multi-depot vehicle routing problem in which vehicles may be replenished at intermediate depots along their route. It proposes a heuristic combining the adaptative memory principle, a tabu search method for the solution of subproblems, and integer programming. Tests are conducted on randomly generated instances.

BACKGROUND Nonadherence with antipsychotic medication is an important clinical and economic problem in the treatment of schizophrenia. This study identified treatment patterns and clinical characteristics that immediately precede the initiation of depot typical antipsychotics in the usual treatment of schizophrenia patients with a recent history of nonadherence with oral antipsychotic regimens....

Glucocorticoids promote fat accumulation in visceral compared to subcutaneous depots, but the molecular mechanisms involved remain poorly understood. To identify long-term changes in gene expression that are differentially sensitive or responsive to glucocorticoids in these depots, paired samples of human omental (Om) and abdominal subcutaneous (Abdsc) adipose tissues obtained from obese women ...

The vehicle routing with pickups and deliveries (VRPD) problem is de6ned over a graph G=(V; E). Some vertices in G represent delivery customers who expect deliveries from a depot, and other vertices in G represent pickup customers who have available supply to be picked up and transported to a depot. The objective is to 6nd a minimum length tour for a capacitated vehicle, which starts at a depot...

The adrenocorticotrophic effects of a synthetic corticotrophin analogue, alpha(1-18) ACTH with D-serine(1), lysine(17), and lysine amide(18) substitutions has been studied. It is effective after both intramuscular and subcutaneous administration and compared with tetracosactrin depot (Synacthen depot, Cortrosyn depot) it has a similarly prolonged time course of action-about 24 hours after 0.5 m...

OBJECTIVE Nonadherence is a major challenge in schizophrenia treatment. While long-acting (depot) antipsychotic medications are often recommended to address adherence problems, evidence on the comparative effectiveness of depot versus oral antipsychotics is inconsistent. We hypothesize that this inconsistency could be due to systematic differences in study design. This review evaluates the effe...

This paper deals with a real-life vehicle delivery routing problem, which is a seafood product delivery routing problem. Considering the features of the seafood product delivery routing problem, this paper formulated this problem as a multi-depot open vehicle routing problem. Since the multi-depot open vehicle routing problem is a very complex problem, a method is used to reduce the complexity ...