Drugs that have antimicrobial, anti-inflammatory and wound-healing effects deserve special attention, sodium-containing drugs are one of them, which is why they used in veterinary medicine.
 The article presents the results experimental studies to study sub-acute toxicity drugs: known – glycetinate 2%, its analogues ovocid 3%, potassium-sodium 1.5% (Na / K, 1.5%).
 was carried out by ...

Silver salts and nanosilver (NS) are the common antimicrobial used in the treatment of chronic wounds, so they are important to assess their dermal toxicity. Therefore, in this study, the possible dermal toxicity of NS particles and silver nitrate (AgNO3), was tested by determining the serum level of transforming growth factor-β1(TGF-β1) and study on of mouse skin tissue. In this stu...

Silver has been used as an antimicrobial agent for a long time in different forms, but silver nanoparticles (nanosilver) have recently been recognized as potent antimicrobial agents. Although nanosilver is finding diverse medical applications such as silver-based dressings and silver-coated medical devices, its dermal and systemic toxicity via dermal use has not yet been identified. In this stu...

The outcome of avian field studies was examined to model the likelihood of mortality. The data were divided into clusters reflecting the type of pesticide application and bird guilds present on site. Logistic regression was used to model the probability of a bird kill. Four independent variables were tested for their explanatory power: a variable reflecting acute oral toxicity and application r...

Acute local toxicity refers to the local toxic effects that may result from a single exposure to a chemical or product, by way of the oral, dermal, ocular or inhalation routes. The exposure can be incidental, accidental or deliberate (for example, in the case of cosmetics and certain medicines). The dermal route of exposure can also be a significant route for entry into the systemic circulation...

To date, special attention should be paid to drugs that have antimicrobial, anti-inflammatory and wound-healing effects, one of which is sodium-containing drugs.
 The article presents the results experimental studies study acute toxicity drugs: glycetinate 2 %, its analogues – ovocid 3 potassium-sodium 1.5% (Na/K 1.5 %). was carried out by applying skin animals. experiment used white rats ...

BACKGROUND Previously, we have reported that most, if not all, of the Scyphozoan jellyfish venoms contain multiple components of metalloproteinases, which apparently linked to the venom toxicity. Further, it is also well known that there is a positive correlation between the inflammatory reaction of dermal tissues and their tissue metalloproteinase activity. Based on these, the use of metallopr...