A new function is proposed for describing the rate of T cell proliferation in response to peptides on antigen-presenting cells. The model improves an earlier model of ours by allowing for a true maximum proliferation rate of the T cells. This is achieved by a simple change of variables that markedly relaxes the conditions for a conventional quasi-steady-state assumption. The new model has the s...

Abstract: In this paper, describing function method is used to analyze the characteristics and parameters selection of differentiators. Nonlinear differentiator is an effective compensation to linear differentiator, and hybrid differentiator consisting of linear and nonlinear parts is the combination of both advantages of linear and nonlinear differentiators. The merits of the hybrid differenti...