BACKGROUND Sjögren's syndrome is an autoimmune disorder caused by the infiltration of monocytes in epithelial glandular and extra-glandular tissues. Hallmark presentations include mouth and eye dryness. Although renal involvement is uncommon in primary Sjögren's syndrome (pSS), patients may experience renal tubular acidosis type I (RTA I), tubulointerstitial nephritis, diabetes insipidus (DI), ...

The syndrome of diabetes insipidus may arise from many different lesions of the hypothalamohypophyseal mechanism. Destruction of the posterior .lobe of the pituitary gland, the hypothalamo-hypophyseal tract, or the supra-optic nuclei bilaterally will produce the symptoms of polyuria and polydipsia, provided the anterior lobe of the pituitary gland remains functionally intact. It is a r-are affe...

Evaluation of the sellar area was performed with magnetic resonance imaging in 101 patients (age range 0.8-27 years) with hypopituitarism, isolated diabetes insipidus, hypogonadotrophic hypogonadism, and central precocious puberty. The hypopituitary patients (n = 70) included multiple pituitary deficiency (n = 23), pituitary deficiency with diabetes insipidus (n = 5), and isolated growth hormon...

THE ability of chlorpropamide to reduce urinary volume in patients with neurogenic diabetes insipidus has been recently described by Arduino, Ferraz & Rodriguez (1966), Meinders, Touber & De Vries (1967), Reforzo-Membrives et al. (1968), Hocken & Longson (1968), and Andreani, Cinotti & Stirati (1969). This therapy is potentially of great importance in the treatment of neurogenic diabetes insipi...

The unusual association of Werdnig-Hoffmann disease and nephrogenic diabetes insipidus in a 5-month-old child is described for the first time. The association is casual, considering the different pathways of genetical transmission in these two diseases. The possibility of identifying the heterozygote is discussed and it appears to be limited to nephrogenic diabetes insipidus.

Central Diabetes Insipidus is often an overlooked complication of cardiopulmonary arrest and anoxic brain injury. We report a case of transient Central Diabetes Insipidus (CDI) following cardiopulmonary arrest. It developed 4 days after the arrest resulting in polyuria and marked hypernatremia of 199 mM. The latter was exacerbated by replacing the hypotonic urine by isotonic saline.

Diabetes insipidus is a metabolic disorder caused by a deficiency in the production of or response to arginine vasopressin (AVP). The lack of, or inability to appropriately respond to, AVP results in a lack of tubular reabsorption of water and urine of low specific gravity. Two main categories of diabetes insipidus are recognized in veterinary medicine: central and nephrogenic.