This study aimed to evaluate in vitro free radical scavenging activity and anti-diabetic properties of extracts from the sprout Borassus fabellifier. Antioxidant was performed using DPPH, ABTS, FRAP, SO, NO inhibition methods. The enzymes (α-amylase α- Glucosidase inhibitory activities were investigated. Moreover, glucose adsorption diffusion also studied confirm potential effect B. fabellifier...

We previously demonstrated that treatment of diabetic peripheral neuropathy with the short (4 hours) half-life phosphodiesterase 5 (PDE5) inhibitor, sildenafil, improved functional outcome in diabetic db/db mice. To further examine the effect of PDE5 inhibition on diabetic peripheral neuropathy, we investigated the effect of another potent PDE5 inhibitor, tadalafil, on diabetic peripheral neuro...

The present study was hypothesized to assess the effect of sildenafil, a phosphodiesterase inhibitor, on proinflammatory cytokines and hyperglycemia-mediated oxidative stress in type 2 diabetic rats. Diabetes was induced by feeding rats with high fat diet for 2 weeks followed by an intraperitoneal injection of streptozotocin. In the diabetic control group, levels of glucose were significantly i...

The role of beta-endorphin in the plasma glucose-lowering action of tetrandrine in streptozotocin-induced diabetic rats (STZ-diabetic rats) was investigated. The plasma glucose concentration was assessed by the glucose oxidase method. The enzyme-linked immunosorbent assay was used to determine the plasma level of beta-endorphin-like immunoreactivity (BER). The mRNA levels of glucose transporter...

Jing Wan Hong ointment contains 30 kinds of Chinese herbs, with functions of activating blood circulation to disperse blood stasis, clearing heat, eliminating dampness, and reducing swelling by detoxification. Therefore, Jing Wan Hong ointment may facilitate the healing of ulcers. The aim of this study was to evaluate the efficacy and mechanisms of Jing Wan Hong ointment for healing diabetic fo...

We have previously shown that acute intravenous injection of the angiotensin-converting enzyme (ACE) inhibitor enalapril in diabetic rats evokes a baroreflex-independent sympathoexcitatory effect that does not occur with angiotensin receptor blockade alone. As ACE inhibition also blocks bradykinin degradation, we sought to determine whether bradykinin mediated this effect. Experiments were perf...

the aim of the present study was to evaluate the effect of ethanolic extract of murraya koenigii leaves (mkl) on blood glucose level and in prevention or management of diabetic neuropathy. in the present study the diabetic neuropathy was developed 9 weeks after single injection of streptozotocin (stz, 70 mg/kg i.v.) in rat. the treatment with mkl (300 and 500 mg/kg p.o.) was started after stabi...

in the present study, we examined the antioxidative activities of satureja khuzestanica essential oil (ske) and possible protective effect of ske on lipid profile, atherogenic index and liver enzyme markers in alloxan-induced type 1 diabetic rats. thirty male rats were randomly divided into three groups; group one as control, group two diabetic untreatment, and group three treatments with ske b...